PMID- 10683304
OWN - NLM
STAT- MEDLINE
DCOM- 20000323
LR  - 20131121
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 161
IP  - 1
DP  - 2000 Jan
TI  - Lesion-induced increase of BDNF is greater in the striatum of young versus old 
      rat brain.
PG  - 392-6
AB  - Young (4-5 month old) and old (32-34 month old) Brown Norway/F344 hybrid rats 
      were given unilateral 6-OHDA lesions of the nigrostriatal pathway. Four weeks 
      later tissue from the lesioned or intact striatum or ventral midbrain was 
      dissected and analyzed for brain-derived neurotrophic factor (BDNF) protein 
      levels using an enzyme-linked immunosorbent assay. BDNF protein content was 
      greater in the lesioned striatum than in the intact striatum for all young rats, 
      and the increased BDNF content in the lesioned striatum of young rats was 
      directly correlated with severity of lesion as determined by rotational scores. 
      BDNF content in the lesioned striatum increased in less than half of the old rats 
      and was not significantly different than BDNF content in the intact striatum. 
      BDNF content in the lesioned substantia nigra/ventral tegmental area (SN/VTA) was 
      greater than BDNF content in the intact SN/VTA for both young and old rats. These 
      data suggest that an age-related difference in activity of at least one 
      neurotrophic factor, BDNF, occur within the denervated striatum following a 
      neurotoxic lesion of the nigrostriatal pathway.
CI  - Copyright 2000 Academic Press.
FAU - Yurek, D M
AU  - Yurek DM
AD  - Department of Neurosurgery, University of Kentucky College of Medicine, 
      Lexington, Kentucky, 40536-0305, USA.
FAU - Fletcher-Turner, A
AU  - Fletcher-Turner A
LA  - eng
GR  - NS35890/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Sympatholytics)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corpus Striatum/*metabolism
MH  - Dopamine/physiology
MH  - Nerve Degeneration/chemically induced/metabolism
MH  - Oxidopamine
MH  - Parkinson Disease, Secondary/chemically induced/*metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rotation
MH  - Sympatholytics
EDAT- 2000/02/23 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/02/23 09:00
PHST- 2000/02/23 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/02/23 09:00 [entrez]
AID - S0014-4886(99)97274-6 [pii]
AID - 10.1006/exnr.1999.7274 [doi]
PST - ppublish
SO  - Exp Neurol. 2000 Jan;161(1):392-6. doi: 10.1006/exnr.1999.7274.