PMID- 10683500
OWN - NLM
STAT- MEDLINE
DCOM- 20000411
LR  - 20190910
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 79
IP  - 1
DP  - 2000 Feb 14
TI  - Medial prefrontal cortex acetylcholine injection-induced hypotension: the role of 
      hindlimb vasodilation.
PG  - 1-7
AB  - The injection of acetylcholine (ACh) into the cingulate region of the medial 
      prefrontal cortex (MPFC) causes a marked fall in arterial blood pressure which is 
      not accompanied by changes in heart rate. The purpose of the present study was to 
      investigate the hemodynamic basis for this stimulus-induced hypotension in 
      Sprague-Dawley rats. The study was designed to determine whether a change in the 
      vascular resistance of hindlimb, renal or mesenteric vascular beds contributes to 
      the fall in arterial pressure in response to ACh injection into the cingulate 
      cortex. Miniature pulsed-Doppler flow probes were used to measure changes in 
      regional blood flow and vascular resistance. The results indicated that the 
      hypotensive response was largely due to a consistent and marked vasodilation in 
      the hindlimb vascular bed. On this basis, an additional experiment was then 
      undertaken to determine the mechanisms that contribute to hindlimb vasodilation. 
      The effect of interrupting the autonomic innervation of one leg on the hindlimb 
      vasodilator response was tested. Unilateral transection of the lumbar sympathetic 
      chain attenuated the cingulate ACh-induced vasodilation in the ipsilateral, but 
      not in the contralateral hindlimb. These results suggest that the hypotensive 
      response to cingulate cortex-ACh injection is caused by skeletal muscle 
      vasodilation mediated by a sympathetic chain-related vasodilator system.
FAU - Crippa, G E
AU  - Crippa GE
AD  - Department of Pharmacology, School of Medicine of Ribeirao Preto-USP, 14049-900, 
      Ribeirao Preto, Brazil.
FAU - Lewis, S J
AU  - Lewis SJ
FAU - Johnson, A K
AU  - Johnson AK
FAU - Correa, F M
AU  - Correa FM
LA  - eng
GR  - HL14388/HL/NHLBI NIH HHS/United States
GR  - HL57472/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - *Acetylcholine/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Gyrus Cinguli/physiology
MH  - Hemodynamics/drug effects
MH  - Hindlimb/*blood supply/innervation
MH  - Hypotension/*chemically induced/physiopathology
MH  - Injections
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sympathectomy
MH  - Sympathetic Nervous System/physiopathology
MH  - *Vasodilation
OTO - NASA
OT  - NASA Discipline Regulatory Physiology
OT  - NASA Program Biomedical Research and Countermeasures
OT  - Non-NASA Center
FIR - Johnson, A K
IR  - Johnson AK
IRAD- U IA, Iowa City
EDAT- 2000/02/23 09:00
MHDA- 2000/04/15 09:00
CRDT- 2000/02/23 09:00
PHST- 2000/02/23 09:00 [pubmed]
PHST- 2000/04/15 09:00 [medline]
PHST- 2000/02/23 09:00 [entrez]
AID - S0165183899000910 [pii]
AID - 10.1016/s0165-1838(99)00091-0 [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 2000 Feb 14;79(1):1-7. doi: 10.1016/s0165-1838(99)00091-0.