PMID- 10683824
OWN - NLM
STAT- MEDLINE
DCOM- 20000316
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 11
IP  - 1
DP  - 2000 Jan 17
TI  - Distribution of PDE4A and G(o) alpha immunoreactivity in the accessory olfactory 
      system of the mouse.
PG  - 27-32
AB  - Distribution of the cAMP-specific phosphodiesterase PDE4A was examined in the 
      accessory olfactory system by immunohistochemistry. Adjacent sections through the 
      vomeronasal organ (VNO) and accessory olfactory bulb (AOB) were alternately 
      immunostained with antibodies against PDE4A or the G-protein alpha subunit G(o) 
      alpha, which labels basal VNO neurons, in order to determine whether PDE4A occurs 
      preferentially in one of two segregated VNO pathways. We found that PDE4A 
      strongly labeled apical VNO neurons and rostral AOB glomeruli. There was 
      virtually no overlap in G(o) alpha and PDE4A staining, and there were no regions 
      of the VNO neuroepithelium or AOB glomeruli not labeled by either antibody. These 
      results identify a potential member of the pheromone transduction cascade in 
      apical neurons, and provide further evidence that the VNO consists of 
      functionally distinct pathways.
FAU - Lau, Y E
AU  - Lau YE
AD  - Department of Psychology, Boston University, MA 02215, USA.
FAU - Cherry, J A
AU  - Cherry JA
LA  - eng
GR  - DC03019/DC/NIDCD NIH HHS/United States
GR  - MH59200/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Pheromones)
RN  - EC 3.1.4.17 (3',5'-Cyclic-AMP Phosphodiesterases)
RN  - EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
SB  - IM
MH  - 3',5'-Cyclic-AMP Phosphodiesterases/*metabolism
MH  - Animals
MH  - Cyclic Nucleotide Phosphodiesterases, Type 4
MH  - Image Processing, Computer-Assisted
MH  - Immunohistochemistry
MH  - Mice
MH  - Olfactory Bulb/cytology/enzymology/*metabolism
MH  - Pheromones
MH  - Signal Transduction/physiology
MH  - Vomeronasal Organ/cytology/enzymology/*metabolism
EDAT- 2000/02/23 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/02/23 09:00
PHST- 2000/02/23 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/02/23 09:00 [entrez]
AID - 10.1097/00001756-200001170-00006 [doi]
PST - ppublish
SO  - Neuroreport. 2000 Jan 17;11(1):27-32. doi: 10.1097/00001756-200001170-00006.