PMID- 10684010
OWN - NLM
STAT- MEDLINE
DCOM- 20000414
LR  - 20161020
IS  - 0257-7712 (Print)
IS  - 0257-7712 (Linking)
VI  - 29
IP  - 2
DP  - 1998 Jun
TI  - [Relationship between tumor cell proliferating activity and biological behavior, 
      prognosis in laryngeal carcinoma].
PG  - 178-81
AB  - Using PC 10, an antibody to proliferating cell nuclear antigen (PCNA) and a 
      standard immunohistochemical staining the authors examined 11 cases of simple 
      hyperplasia of epithelium (SHE), 32 cases of atypical hyperplasia of epithelium 
      (AHE) and 42 cases of laryngeal squamous cell carcinoma (LSCC) for expression of 
      PCNA, a protein associated with DNA polymerase dalta and DNA replication, a 
      marker for tumor cell proliferation. The results revealed that PCNA indices in 
      SHE, AHE and LSCC were 9.5%, 27.33% and 68.05%, respectively. The PCNA indices 
      were 63.68%, 69.57%, 71.18% in the well, moderately and poorly differentiated 
      LSCC, respectively, there were significant differences. The PCNA indices were 
      63.88%, 70.82%, 66.20% and 69.04%, respectively in stages I, II, III, and IV of 
      LSCC; no significance was found. There was a strong negative correlation betwee 
      survival time and the tumor cell proliferative activity (r = 0.6243). PCNA might 
      provide a useful tool for studying cell proliferation in situ under normal and 
      pathological condition.
FAU - Zhou, G
AU  - Zhou G
AD  - Department of Otolaryngology, First Affiliated Hospital, Chengdu.
FAU - Liang, C
AU  - Liang C
FAU - Lin, D
AU  - Lin D
FAU - Zhang, X
AU  - Zhang X
FAU - Wen, D
AU  - Wen D
FAU - Liu, Y
AU  - Liu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Yi Ke Da Xue Xue Bao
JT  - Hua xi yi ke da xue xue bao = Journal of West China University of Medical 
      Sciences = Huaxi yike daxue xuebao
JID - 8609552
RN  - 0 (Proliferating Cell Nuclear Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*pathology/secondary
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*pathology
MH  - Laryngectomy
MH  - Larynx/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Precancerous Conditions/*pathology
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Survival Rate
EDAT- 2000/02/23 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/02/23 09:00
PHST- 2000/02/23 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/02/23 09:00 [entrez]
PST - ppublish
SO  - Hua Xi Yi Ke Da Xue Xue Bao. 1998 Jun;29(2):178-81.