PMID- 10684070
OWN - NLM
STAT- MEDLINE
DCOM- 20000328
LR  - 20161020
IS  - 0257-7712 (Print)
IS  - 0257-7712 (Linking)
VI  - 28
IP  - 1
DP  - 1997 Mar
TI  - [Changes of serum TNF-alpha level, t-PA activivty and PAI activity in patients 
      with silent myocardial ischemia or silent cerebral ischemia].
PG  - 81-3
AB  - Tumor necrosis factor-alpha (TNF-alpha) level, tissue-typed plasminogen 
      activator(t-PA) activity and PA inhibitor (PAI) activity were determined in three 
      groups: (1) 25 NIDDM patients with silent myocardial ischemia (SMI) or silent 
      cerebral ischemia (SCI); (2) 18NIDDM patients without SMI or SCI; (3) 20 
      age-matched normal controls. Diagnosis of SMI or SCI was based on the finding of 
      ischemic evidence by SPECT of myocardiotomograph or cerebrotomograph. All 
      patients ECG and blood pressure were normal, and they had no history of clinical 
      symptoms and signs of MI or CI. The result showed that the TNF-alpha level and 
      PAI activity in the ischemia group were the highest and the t-PA activity in the 
      ischemia group was the lowest, as compared with those in the other two groups 
      respectively. It suggests that in NIDDM patients who have high TNF-alpha, high 
      PAI activity, low t-PA, and even no symptoms and signs of MI or CI, anticoagulant 
      therapy might be useful to prevent the progression of diabetic macroangiopathies.
FAU - Tong, N
AU  - Tong N
AD  - Department of Medicine, First Affiliated Hospital, Chengdu.
FAU - Li, Y
AU  - Li Y
FAU - Liang, J
AU  - Liang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Yi Ke Da Xue Xue Bao
JT  - Hua xi yi ke da xue xue bao = Journal of West China University of Medical 
      Sciences = Huaxi yike daxue xuebao
JID - 8609552
RN  - 0 (Plasminogen Inactivators)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
SB  - IM
MH  - Brain Ischemia/*blood/complications
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*blood/complications
MH  - Plasminogen Inactivators/blood
MH  - Tissue Plasminogen Activator/*metabolism
MH  - Tomography, Emission-Computed, Single-Photon
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1997/03/01 00:00
MHDA- 2000/04/01 09:00
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 1997/03/01 00:00 [entrez]
PST - ppublish
SO  - Hua Xi Yi Ke Da Xue Xue Bao. 1997 Mar;28(1):81-3.