PMID- 10684291
OWN - NLM
STAT- MEDLINE
DCOM- 20000403
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 74
IP  - 6
DP  - 2000 Mar
TI  - A novel mechanism of resistance to mouse mammary tumor virus infection.
PG  - 2752-9
AB  - Exogenous mouse mammary tumor virus (MMTV) is carried from the gut of suckling 
      pups to the mammary glands by lymphocytes and induces mammary gland tumors. 
      MMTV-induced tumor incidence in inbred mice of different strains ranges from 0 to 
      as high as 100%. For example, mice of the C3H/HeN strain are highly susceptible, 
      whereas mice of the I/LnJ strain are highly resistant. Of the different factors 
      that together determine the susceptibility of mice to development of MMTV-induced 
      mammary tumors, genetic elements play a major role, although very few genes that 
      determine a susceptibility-resistance phenotype have been identified so far. Our 
      data indicate that MMTV fails to infect mammary glands in I/LnJ mice foster 
      nursed on viremic C3H/HeN females, even though the I/LnJ mammary tissue is not 
      refractory to MMTV infection. Lymphocytes from fostered I/LnJ mice contained 
      integrated MMTV proviruses and shed virus but failed to establish infection in 
      the mammary glands of susceptible syngeneic (I x C3H.JK)F(1) females. Based on 
      the susceptible-resistant phenotype distribution in N(2) females, both MMTV 
      mammary gland infection and mammary gland tumor development in I/LnJ mice are 
      controlled by a single locus.
FAU - Golovkina, T V
AU  - Golovkina TV
AD  - The Jackson Laboratory, Bar Harbor, Maine 04609, USA. tvg@aretha.jax.org
LA  - eng
GR  - P30 CA034196/CA/NCI NIH HHS/United States
GR  - CA34196/CA/NCI NIH HHS/United States
GR  - CA65795/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - B-Lymphocytes/cytology/immunology/virology
MH  - CD4-Positive T-Lymphocytes/cytology/immunology/virology
MH  - Cells, Cultured
MH  - Chromosome Mapping
MH  - DNA, Viral/analysis
MH  - Female
MH  - Genes, Recessive
MH  - Immunity, Innate/genetics/immunology
MH  - Male
MH  - Mammary Glands, Animal/immunology/virology
MH  - Mammary Neoplasms, Experimental/genetics/*immunology/virology
MH  - Mammary Tumor Virus, Mouse/genetics/*immunology/isolation & purification
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Neurologic Mutants/genetics/immunology
MH  - Retroviridae Infections/genetics/*immunology/virology
MH  - Tumor Virus Infections/genetics/*immunology/virology
MH  - Virus Shedding
PMC - PMC111765
EDAT- 2000/02/23 00:00
MHDA- 2000/02/23 00:01
PMCR- 2000/03/01
CRDT- 2000/02/23 00:00
PHST- 2000/02/23 00:00 [pubmed]
PHST- 2000/02/23 00:01 [medline]
PHST- 2000/02/23 00:00 [entrez]
PHST- 2000/03/01 00:00 [pmc-release]
AID - 1225 [pii]
AID - 10.1128/jvi.74.6.2752-2759.2000 [doi]
PST - ppublish
SO  - J Virol. 2000 Mar;74(6):2752-9. doi: 10.1128/jvi.74.6.2752-2759.2000.