PMID- 10686943
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 112
IP  - 2
DP  - 1999 Jul 15
TI  - Unusual chromosome patterns of renal cell carcinomas common to two brothers.
PG  - 149-55
AB  - In this study, we describe two renal cell carcinomas (RCC) that occurred at the 
      same time in two brothers, yielding information on the carcinogenic process. We 
      used flow cytometry (FCM) to evaluate nuclear DNA content, and performed 
      cytogenetic analysis. We also carried out fluorescence in situ hybridization 
      (FISH) with a panel of centromeric probes for chromosomes 3, 7, 8, 9, 12, 17, 20, 
      and Y in interphase cells. Flow cytometry analysis revealed diploid histograms in 
      the tumor and "nonmalignant" samples of patient 1, while an aneuploid cell 
      subpopulation was found in the tumor and "nonmalignant" samples of patient 2. 
      Tumor samples from the two brothers were studied by FISH, and had common 
      numerical chromosome aberrations: trisomy of chromosomes 3 and 7, and monosomy 
      and trisomy of chromosomes 9 and 17. Moreover, in normal samples from both 
      brothers, we found monosomy 9, and in a normal sample from patient 1, monosomy 
      17. Cytogenetic analysis revealed trisomy 3 in some cells grown from normal 
      kidney tissue of each brother. The identification of the same chromosome 
      alterations in both brothers appears to provide evidence of an unusual process of 
      carcinogenesis, probably due to a common genetic basis.
FAU - De Vita, R
AU  - De Vita R
AD  - Unit of Environmental Epidemiology, ENEA Casaccia, Rome, Italy.
FAU - Eleuteri, P
AU  - Eleuteri P
FAU - Pomponi, D
AU  - Pomponi D
FAU - Calugi, G
AU  - Calugi G
FAU - Nesci, L
AU  - Nesci L
FAU - Giuseppa Grollino, M
AU  - Giuseppa Grollino M
FAU - Gallucci, M
AU  - Gallucci M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Carcinoma, Renal Cell/*genetics
MH  - *Chromosome Aberrations
MH  - Flow Cytometry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Nuclear Family
EDAT- 2000/02/25 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/02/25 09:00
PHST- 2000/02/25 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/02/25 09:00 [entrez]
AID - S0165460898002623 [pii]
AID - 10.1016/s0165-4608(98)00262-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jul 15;112(2):149-55. doi: 
      10.1016/s0165-4608(98)00262-3.