PMID- 10688046
OWN - NLM
STAT- MEDLINE
DCOM- 20000317
LR  - 20191210
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 279
IP  - 3
DP  - 2000 Feb 4
TI  - Muscle weakness, hyperactivity, and impairment in fear conditioning in 
      tau-deficient mice.
PG  - 129-32
AB  - Tau, one of the major neuronal microtubule-associated proteins (MAPs), is 
      important for neuronal cell morphogenesis and axonal maintenance. Tau is also 
      known to be a component of the paired helical filaments (PHFs) in Alzheimer's 
      disease patients. Recently, mutations in the tau gene were found in a hereditary 
      neurodegenerative disease called frontotemporal dementia and parkinsonism linked 
      to chromosome 17 (FTDP-17) which exhibits various neurological and 
      neuropathological characteristics including PHF-like intracellular tau deposit 
      formation. Currently, the phenotype of the disease is thought to be due to: (1) 
      the toxicity of mutant tau molecules and and/or; (2) the loss of function of 
      normal tau molecules in patients' brains. To test the latter hypothesis, we 
      performed behavioral and neurological tests on tau-deficient mice. Tau-deficient 
      mice showed muscle weakness in the wire-hanging test, hyperactivity in a novel 
      environment, and impairment in the contextual fear conditioning. They also had a 
      tendency to fall more easily in the rod-walking test. These phenotypes parallel 
      some signs and symptoms of FTDP-17 patients. Our results show that the loss of 
      tau protein may itself lead to some of the neurological characteristics observed 
      in FTDP-17 patients.
FAU - Ikegami, S
AU  - Ikegami S
AD  - Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
FAU - Harada, A
AU  - Harada A
FAU - Hirokawa, N
AU  - Hirokawa N
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/physiology
MH  - Brain/physiopathology
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Conditioning, Psychological/*physiology
MH  - Fear/*physiology
MH  - Humans
MH  - Hyperkinesis/*physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Muscle Weakness/*physiopathology
MH  - Neurodegenerative Diseases/physiopathology
MH  - Parkinsonian Disorders/physiopathology
MH  - tau Proteins/*deficiency/*genetics/metabolism
EDAT- 2000/02/25 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/02/25 09:00
PHST- 2000/02/25 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/02/25 09:00 [entrez]
AID - S0304394099009647 [pii]
AID - 10.1016/s0304-3940(99)00964-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 2000 Feb 4;279(3):129-32. doi: 10.1016/s0304-3940(99)00964-7.