PMID- 10689118
OWN - NLM
STAT- MEDLINE
DCOM- 20000327
LR  - 20231213
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 61
IP  - 3
DP  - 2000 Mar
TI  - The HLA-E locus is associated with age at onset and susceptibility to type 1 
      diabetes mellitus.
PG  - 290-5
AB  - Previous studies have suggested that the human leukocyte antigen (HLA) class I 
      region may be involved in determining the age at onset and clinical severity of 
      type 1 diabetes. We have investigated the frequency of polymorphisms of the 
      nonclassical HLA class I gene, HLA-E, in 199 British Caucasian patients with type 
      1 diabetes and 82 healthy controls. A highly significant increase in the 
      frequency of the HLA-E 0101 genotype was found in the patients compared to 
      controls (chi(2) = 15.3, p < 0.00009). The frequency of the HLA-E 0101 genotype 
      was increased in those patients diagnosed after 10 years of age, while the 
      frequency of the 0101, 0103 genotype was significantly increased in those 
      subjects diagnosed before 10 years of age (chi(2) = 26.0 p < 0.000003 and chi(2) 
      = 13.0 p < 0.0003, respectively). No obvious interaction between the HLA-E locus 
      and the class II DQB1*0201, 0302, and 0501 susceptibility alleles was found. This 
      is the first report of an association between the HLA-E locus and susceptibility 
      to an autoimmune disease.
FAU - Hodgkinson, A D
AU  - Hodgkinson AD
AD  - Molecular Medicine Research Group, Plymouth Postgraduate Medical School, 
      University of Plymouth, ITTC Building, Tamar Science Park, Plymouth, England, 
      United Kingdom.
FAU - Millward, B A
AU  - Millward BA
FAU - Demaine, A G
AU  - Demaine AG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Age of Onset
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - United Kingdom
MH  - White People
MH  - HLA-E Antigens
EDAT- 2000/02/26 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/02/26 09:00
PHST- 2000/02/26 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/02/26 09:00 [entrez]
AID - S0198-8859(99)00116-0 [pii]
AID - 10.1016/s0198-8859(99)00116-0 [doi]
PST - ppublish
SO  - Hum Immunol. 2000 Mar;61(3):290-5. doi: 10.1016/s0198-8859(99)00116-0.