PMID- 10689124
OWN - NLM
STAT- MEDLINE
DCOM- 20000327
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 61
IP  - 3
DP  - 2000 Mar
TI  - HLA class II haplotype associations with inflammatory bowel disease in Jewish 
      (Ashkenazi) and non-Jewish caucasian populations.
PG  - 326-33
AB  - Ulcerative colitis (UC) and Crohn's disease (CD) are the clinical entities 
      comprising idiopathic inflammatory bowel disease (IBD). Previous studies on the 
      association of IBD and human leukocyte antigen (HLA) class II genes suggested a 
      role for HLA in this disease. Here we present HLA class II (DRB1, DQB1, DQA1, 
      DPB1) allele and haplotype distributions determined using the polymerase chain 
      reaction and sequence-specific oligonucleotide probe methods. A total of 578 UC 
      and CD Caucasian patients and controls from Jewish (Ashkenazi) and non-Jewish 
      populations was examined. Our previously reported association of DR1-DQ5 with CD 
      was attributable to DRB1*0103. A dramatic association with IBD and the highly 
      unusual DRB1*0103-DQA1*0501-DQB1*0301 haplotype (OR = 6.6, p = 0.036) was found. 
      The more common DR1 haplotype, DRB1*0103-DQA1*0101-DQB1*0501, was also associated 
      with IBD (OR = 3.1, p = 0.014), a result suggesting that interaction between DR 
      and DQ may determine the extent of disease risk. Our previously reported 
      association of DR2 with UC was attributable to DRB1*1502 (OR = 2.6, p = 0.006). 
      At the DPB1 locus, a significant association of DPB1*0401 with CD was observed 
      for the combined populations (OR = 1.85, p = 0.007). These observations indicate 
      that some class II alleles and haplotypes confer susceptibility to both UC and 
      CD, implying common immunogenetic mechanisms of pathogenesis, while others confer 
      risk to only one of these diseases, and illustrate the value of DNA HLA typing in 
      disease susceptibility analyses.
FAU - Trachtenberg, E A
AU  - Trachtenberg EA
AD  - Children's Hospital Oakland Research Institute, Oakland, CA, USA. 
      etrachtenberg@mail.cho.org
FAU - Yang, H
AU  - Yang H
FAU - Hayes, E
AU  - Hayes E
FAU - Vinson, M
AU  - Vinson M
FAU - Lin, C
AU  - Lin C
FAU - Targan, S R
AU  - Targan SR
FAU - Tyan, D
AU  - Tyan D
FAU - Erlich, H
AU  - Erlich H
FAU - Rotter, J I
AU  - Rotter JI
LA  - eng
GR  - P01 DK046763/DK/NIDDK NIH HHS/United States
GR  - DK46763/DK/NIDDK NIH HHS/United States
GR  - DK54967/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - California
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/ethnology/genetics/immunology
MH  - Crohn Disease/ethnology/genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-D Antigens/*genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Inflammatory Bowel Diseases/ethnology/*genetics/immunology
MH  - Jews/*genetics
MH  - Male
MH  - White People/*genetics
PMC - PMC4524574
MID - NIHMS697773
EDAT- 2000/02/26 09:00
MHDA- 2000/04/01 09:00
PMCR- 2015/08/04
CRDT- 2000/02/26 09:00
PHST- 2000/02/26 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/02/26 09:00 [entrez]
PHST- 2015/08/04 00:00 [pmc-release]
AID - S0198-8859(99)00134-2 [pii]
AID - 10.1016/s0198-8859(99)00134-2 [doi]
PST - ppublish
SO  - Hum Immunol. 2000 Mar;61(3):326-33. doi: 10.1016/s0198-8859(99)00134-2.