PMID- 10689175
OWN - NLM
STAT- MEDLINE
DCOM- 20000421
LR  - 20181130
IS  - 0378-1097 (Print)
IS  - 0378-1097 (Linking)
VI  - 184
IP  - 1
DP  - 2000 Mar 1
TI  - The extracellular hyaluronidase gene (hylA) of Streptococcus pyogenes.
PG  - 109-12
AB  - Group A streptococci produce an extracellular hyaluronidase (hyaluronate lyase) 
      which may be associated with the spread of the organism during infection. The 
      gene for this hyaluronidase (hylA) encodes an 868 amino acid protein with a 
      molecular size of 99636 Da. Cleavage of the proposed signal peptide results in an 
      extracellular protein of 95941 Da. Comparison with other bacterial hyaluronidases 
      indicates strong similarities to the genes from Streptococcus pneumoniae, 
      Streptococcus agalactiae and Staphylococcus aureus. A region internal to the hylA 
      gene was amplified from all 175 strains of Streptococcus pyogenes tested 
      suggesting a widespread distribution of the gene.
FAU - Hynes, W L
AU  - Hynes WL
AD  - Department of Biological Sciences, Old Dominion University, Norfolk, VA 
      23529-0266, USA. whynes@odu.edu
FAU - Dixon, A R
AU  - Dixon AR
FAU - Walton, S L
AU  - Walton SL
FAU - Aridgides, L J
AU  - Aridgides LJ
LA  - eng
SI  - GENBANK/AF218838
GR  - 1R15AI43029/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEMS Microbiol Lett
JT  - FEMS microbiology letters
JID - 7705721
RN  - 0 (DNA, Bacterial)
RN  - EC 3.2.1.35 (Hyaluronoglucosaminidase)
SB  - IM
MH  - DNA, Bacterial/chemistry/genetics
MH  - Hyaluronoglucosaminidase/*genetics
MH  - Molecular Sequence Data
MH  - Sequence Analysis, DNA
MH  - Streptococcus pyogenes/enzymology/*genetics
EDAT- 2000/02/26 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/02/26 09:00
PHST- 2000/02/26 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/02/26 09:00 [entrez]
AID - S0378-1097(00)00029-X [pii]
AID - 10.1111/j.1574-6968.2000.tb08999.x [doi]
PST - ppublish
SO  - FEMS Microbiol Lett. 2000 Mar 1;184(1):109-12. doi: 
      10.1111/j.1574-6968.2000.tb08999.x.