PMID- 10692059
OWN - NLM
STAT- MEDLINE
DCOM- 20000317
LR  - 20190722
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 39
IP  - 2
DP  - 2000 Feb
TI  - Search for evidence of a Th2 profile in HIV+ patients.
PG  - 109-15
AB  - BACKGROUND: Hypersensitivity dermatoses are common in human immunodeficiency 
      virus-positive (HIV+) patients, particularly as the disease progresses. Studies 
      have shown that a switch to T-helper 2 (Th2) might represent a turning point in 
      HIV. This study investigated whether increases in the number of skin mast cells, 
      immunoglobulin E (IgE) serum levels, and eosinophilia, involved in the Th2 
      response in allergic disease, might also be present in HIV+ patients. If so, 
      these alterations might explain one of the mechanisms of skin hypersensitivity in 
      these patients. METHODS: Forty-five skin biopsies from the normal skin of the 
      upper arm of HIV+ patients and 15 controls were included in the study. HIV+ 
      individuals were classified into three equal categories according to their 
      immunologic status: Category I (< 200/microL), Category II (200-499/microL), and 
      Category III (> 500/microL). Anti-tryptase antibody was employed in tissue 
      sections to show mast cells; IgE serum levels and eosinophils in peripheral blood 
      count were investigated; delayed-type hypersensitivity (DTH) skin tests 
      (candidin, trichophytin, and PPD 2U) were evaluated. RESULTS: Normal cutaneous 
      mast cell and eosinophil counts were the same in all categories and in the 
      control group, but increased IgE levels (P < 0. 01) and DTH skin test anergy (P < 
      0.006) were observed among acquired immunodeficiency syndrome (AIDS) patients. 
      CONCLUSIONS: The density of skin mast cells in HIV infection was not modified in 
      the course of the disease. Mast cells do not seem to be primarily responsible for 
      triggering hypersensitivity dermatoses among AIDS patients, although data in 
      support of the Th2 response, as seen in increased IgE serum levels and DTH 
      anergy, are present.
FAU - Galhardo, M C
AU  - Galhardo MC
AD  - Centro de Pesquisa-Evandro Chagas, Laboratorio de AIDS & Imunologia Molecular, 
      Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.
FAU - Perez, M
AU  - Perez M
FAU - Morgado, M G
AU  - Morgado MG
FAU - Almeida, S
AU  - Almeida S
FAU - De Azevedo, L M
AU  - De Azevedo LM
FAU - Georg, I
AU  - Georg I
FAU - Ferreira, H
AU  - Ferreira H
FAU - Sarno, E N
AU  - Sarno EN
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - CD4-Positive T-Lymphocytes/cytology
MH  - Cell Count
MH  - Eosinophils/cytology
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Seropositivity/blood/*immunology
MH  - Humans
MH  - Hypersensitivity, Delayed/immunology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mast Cells/cytology
MH  - Middle Aged
MH  - Skin/cytology/immunology
MH  - Skin Diseases/immunology
MH  - Th2 Cells/cytology/*immunology
EDAT- 2000/02/26 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/02/26 09:00
PHST- 2000/02/26 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/02/26 09:00 [entrez]
AID - ijd858 [pii]
AID - 10.1046/j.1365-4362.2000.00858.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2000 Feb;39(2):109-15. doi: 10.1046/j.1365-4362.2000.00858.x.