PMID- 10692146
OWN - NLM
STAT- MEDLINE
DCOM- 20000329
LR  - 20190921
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 12
IP  - 1
DP  - 2000 Jan
TI  - Differential effects of placental restriction on IGF-II, ACTH receptor and 
      steroidogenic enzyme mRNA levels in the foetal sheep adrenal.
PG  - 79-85
AB  - We have investigated the effects of restriction of placental growth on foetal 
      adrenal growth and adrenal expression of mRNAs for Insulin-like Growth Factor II 
      (IGF-II), the IGF binding protein IGFBP-2, Steroidogenic Factor 1 (SF-1) and 
      adrenocorticotrophic hormone (ACTH) receptor (ACTH-R) and the steroidogenic 
      cytochrome P-450 enzymes: cholesterol side chain cleavage (CYP11A1), 
      17alpha-hydroxylase (CYP17) and 21-hydroxylase (CYP21A1); and 
      3beta-hydroxysteroid dehydrogenase/Delta5Delta4 isomerase (3betaHSD). Endometrial 
      caruncles were removed from non-pregnant ewes before mating (placental 
      restriction group; PR). The total adrenal: foetal weight ratio was higher in PR 
      (n=6 foetuses) than in control foetuses (n=6 foetuses). There was no difference 
      in plasma ACTH concentrations between the PR and control foetuses between 130 and 
      140 days gestation. Adrenal IGF-II mRNA levels were lower (P<0.05) in the PR 
      group, however, adrenal IGFBP-2 mRNA levels were not different between the PR and 
      control groups. Adrenal ACTH-R mRNA levels were also lower whilst CYP11A1 mRNA 
      levels were increased (P<0.005) in the PR group. We conclude that foetal adrenal 
      growth and steroidogenesis are stimulated as a consequence of foetal growth 
      restriction and that factors other than ACTH are important in foetal adrenal 
      activation during chronic, sustained hypoxaemia.
FAU - Ross, J T
AU  - Ross JT
AD  - Department of Physiology, The University of Adelaide, Adelaide 5005, SA, 
      Australia.
FAU - Phillips, I D
AU  - Phillips ID
FAU - Simonetta, G
AU  - Simonetta G
FAU - Owens, J A
AU  - Owens JA
FAU - Robinson, J S
AU  - Robinson JS
FAU - McMillen, I C
AU  - McMillen IC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Corticotropin)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.1.1.145 (Progesterone Reductase)
RN  - EC 1.14.14.16 (Steroid 21-Hydroxylase)
RN  - EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase)
RN  - EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme)
RN  - EC 5.3.3.- (Steroid Isomerases)
SB  - IM
MH  - Adrenal Glands/*embryology/metabolism
MH  - Animals
MH  - Cholesterol Side-Chain Cleavage Enzyme/genetics
MH  - Cytochrome P-450 Enzyme System/*genetics
MH  - Female
MH  - Fetus/physiology
MH  - Insulin-Like Growth Factor II/*genetics
MH  - Multienzyme Complexes/*genetics
MH  - Organ Size
MH  - Placenta/*physiology
MH  - Pregnancy
MH  - Progesterone Reductase/*genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Corticotropin/*genetics
MH  - Reference Values
MH  - Sheep
MH  - Steroid 17-alpha-Hydroxylase/genetics
MH  - Steroid 21-Hydroxylase/genetics
MH  - Steroid Isomerases/*genetics
MH  - *Transcription, Genetic
EDAT- 2000/02/26 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/02/26 09:00
PHST- 2000/02/26 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/02/26 09:00 [entrez]
AID - jne429 [pii]
AID - 10.1046/j.1365-2826.2000.00429.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2000 Jan;12(1):79-85. doi: 10.1046/j.1365-2826.2000.00429.x.