PMID- 10694476
OWN - NLM
STAT- MEDLINE
DCOM- 20000331
LR  - 20071114
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 269
IP  - 1
DP  - 2000 Mar 5
TI  - Cloning and characterization of the human retinoid X receptor alpha gene: 
      conservation of structure with the mouse homolog.
PG  - 54-7
AB  - Retinoid X receptors (RXRs) are members of the steroid/thyroid hormone receptor 
      superfamily which, along with retinoic acid receptors (RARs), mediate the 
      biological effects of retinoids. These effects include the regulation of many 
      aspects of embryonic development, reproductive and visual function, and the 
      maintenance of epithelial homeostasis throughout life. The genes for three 
      distinct retinoid X receptors, RXRalpha, beta, and gamma, have been localized to 
      separate chromosomes. In order to determine the organization of the human 
      RXRalpha gene, we have isolated a clone containing the majority of the gene from 
      a human genomic bacterial artificial chromosome (BAC) library and generated a 
      physical map. The gene spans over 40 kilobases in size and contains at least 10 
      exons. Comparison with mapped portions of the mouse RXRalpha gene indicates 
      highly conserved intron-exon positioning. These results provide information 
      necessary to generate constructs for targeting the RXRalpha gene in human cell 
      lines, which may eventually lead to an understanding of the function of RXRalpha 
      in human cancer.
CI  - Copyright 2000 Academic Press.
FAU - Li, G
AU  - Li G
AD  - Department of Clinical Cancer Prevention, University of Texas M. D. Anderson 
      Cancer Center, Houston, Texas 77030, USA.
FAU - Walch, E
AU  - Walch E
FAU - Yang, X
AU  - Yang X
FAU - Lippman, S M
AU  - Lippman SM
FAU - Clifford, J L
AU  - Clifford JL
LA  - eng
SI  - GENBANK/AQ917566
SI  - GENBANK/AQ917567
SI  - GENBANK/AQ917568
SI  - GENBANK/AQ917569
SI  - GENBANK/AQ917570
SI  - GENBANK/AQ917571
SI  - GENBANK/AQ917572
SI  - GENBANK/AQ917573
SI  - GENBANK/AQ917574
SI  - GENBANK/AQ917575
SI  - GENBANK/AQ917576
SI  - GENBANK/AQ917577
SI  - GENBANK/AQ917578
SI  - GENBANK/AQ917579
SI  - GENBANK/AQ917580
SI  - GENBANK/AQ917581
SI  - GENBANK/AQ917582
SI  - GENBANK/AQ917583
GR  - CA78560-01/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - DNA Primers/genetics
MH  - Exons
MH  - Gene Library
MH  - Humans
MH  - Introns
MH  - Mice
MH  - Molecular Sequence Data
MH  - Physical Chromosome Mapping
MH  - Polymerase Chain Reaction
MH  - Receptors, Retinoic Acid/*genetics
MH  - Retinoid X Receptors
MH  - Species Specificity
MH  - Transcription Factors/*genetics
EDAT- 2000/03/01 00:00
MHDA- 2000/03/01 00:01
CRDT- 2000/03/01 00:00
PHST- 2000/03/01 00:00 [pubmed]
PHST- 2000/03/01 00:01 [medline]
PHST- 2000/03/01 00:00 [entrez]
AID - S0006-291X(00)92244-7 [pii]
AID - 10.1006/bbrc.2000.2244 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Mar 5;269(1):54-7. doi: 10.1006/bbrc.2000.2244.