PMID- 10695562
OWN - NLM
STAT- MEDLINE
DCOM- 20000328
LR  - 20061115
IS  - 0867-5910 (Print)
IS  - 0867-5910 (Linking)
VI  - 50
IP  - 5
DP  - 1999 Dec
TI  - CagA-positive Helicobacter pylori infection may increase the risk of food allergy 
      development.
PG  - 827-31
AB  - The aim of this study was to test whether patients with symptomatic food allergy 
      and significant levels of immunoglobulin E (IgE) to alimentary antigens were more 
      likely infected by H. pylori, especially by strains expressing the CagA protein, 
      with respect to controls. A group of 38 patients with symptomatic food allergy 
      and 53 age-matched controls were examined serologically for H. pylori infectious 
      status, and for CagA seropositivity. IgE to alimentary allergens were measured by 
      a commercial kit. The prevalence of H. pylori infection in patients with food 
      allergy and controls was similar (42.1%, and 48.3%, respectively). However, 
      anti-CagA antibodies in H. pylori-infected persons were detected in 62.5% of 
      patients with food allergy, and 28% of controls (P = 0.030, odds ratio = 4.29). 
      The mean level of IgE to the most common alimentary antigens in serum samples 
      from infected patients with anti-CagA antibodies was significantly higher than in 
      CagA-negative infected patients: 3.28 kU/L (SD 3.93), vs. 1.99 kU/L (SD 1.53), P 
      = 0.002, 95% confidence interval = 0.61 to 2.53). Infection by CagA-positive H. 
      pylori increases the risk of developing food allergy.
FAU - Figura, N
AU  - Figura N
AD  - Institute of Internal Medicine, University of Siena, Italy. figura@unisi.it
FAU - Perrone, A
AU  - Perrone A
FAU - Gennari, C
AU  - Gennari C
FAU - Orlandini, G
AU  - Orlandini G
FAU - Giannace, R
AU  - Giannace R
FAU - Lenzi, C
AU  - Lenzi C
FAU - Vagliasindi, M
AU  - Vagliasindi M
FAU - Bianciardi, L
AU  - Bianciardi L
FAU - Rottoli, P
AU  - Rottoli P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - J Physiol Pharmacol
JT  - Journal of physiology and pharmacology : an official journal of the Polish 
      Physiological Society
JID - 9114501
RN  - 0 (Allergens)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Proteins)
RN  - 0 (cagA protein, Helicobacter pylori)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.5.1.5 (Urease)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Antigens, Bacterial/immunology
MH  - Bacterial Proteins/*biosynthesis/immunology
MH  - Blotting, Western
MH  - Child
MH  - Food Hypersensitivity/blood/immunology/*microbiology
MH  - Helicobacter Infections/blood/epidemiology/*immunology
MH  - Helicobacter pylori/*immunology/*metabolism
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Urease/immunology
EDAT- 2000/03/01 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/01 09:00
PHST- 2000/03/01 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/01 09:00 [entrez]
PST - ppublish
SO  - J Physiol Pharmacol. 1999 Dec;50(5):827-31.