PMID- 10695778
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20181130
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 30
IP  - 1
DP  - 1999 Mar
TI  - The effects of quinine and artesunate treatment on plasma tumor necrosis factor 
      levels in malaria-infected patients.
PG  - 7-10
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an endogenous mediator of shock and 
      inflammation including malaria. Many lines of evidence suggest that 
      cytoadherence, the life-threatening pathology associated with complicated and 
      cerebral malaria, results from the overproduction of TNF in response to malarial 
      parasite. Quinine has been shown to inhibit TNF synthesis and cytoadherence in 
      vitro suggesting an additional beneficial effect of quinine on its anti-TNF 
      action. On the other hand, artesunate inhibits cytoadherence better than quinine 
      does not suppress TNF production in vitro. The present study compares the effect 
      of artesunate and quinine on TNF levels of malaria-infected patients. 
      Surprisingly, plasma TNF levels increased dramatically after quinine 
      administration but did not increase after artesunate administration. This 
      difference may be explained by previous observations showing that artesunate 
      kills parasites in vitro and clears parasitemias in vivo for more rapidly than 
      quinine. The rapid clearance of plasma TNF in quinine treated patients might be 
      due to the drug's TNF-suppressive activity.
FAU - Ittarat, W
AU  - Ittarat W
AD  - Department of Clinical Microscopy, Faculty of Medical Technology, Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand. mtwit@mahidol.ac.th
FAU - Udomsangpetch, R
AU  - Udomsangpetch R
FAU - Chotivanich, K T
AU  - Chotivanich KT
FAU - Looareesuwan, S
AU  - Looareesuwan S
LA  - eng
GR  - 5 U01 AI35827/AI/NIAID NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 0 (Sesquiterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 60W3249T9M (Artesunate)
RN  - A7V27PHC7A (Quinine)
SB  - IM
MH  - Adult
MH  - Antimalarials/pharmacology/*therapeutic use
MH  - *Artemisinins
MH  - Artesunate
MH  - Cell Adhesion/drug effects
MH  - Drug Monitoring/methods
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Malaria, Falciparum/*blood/*drug therapy/immunology/parasitology
MH  - Male
MH  - Middle Aged
MH  - Quinine/pharmacology/*therapeutic use
MH  - Sesquiterpenes/pharmacology/*therapeutic use
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*analysis/*drug effects
EDAT- 2000/03/01 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/03/01 09:00
PHST- 2000/03/01 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/03/01 09:00 [entrez]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 1999 Mar;30(1):7-10.