PMID- 10696239
OWN - NLM
STAT- MEDLINE
DCOM- 20000310
LR  - 20191024
IS  - 0740-7750 (Print)
IS  - 0740-7750 (Linking)
VI  - 24
IP  - 5
DP  - 1998 Sep
TI  - Chromosomal localization and genomic structure of the human arsenite-stimulated 
      ATPase (hASNA-I).
PG  - 307-11
AB  - The hASNA-I is a novel human arsenite-stimulated ATPase identified as the human 
      paralogue of the ATPase component of the arsenite efflux system in E. coli. The 
      hASNA-I has distinct biochemical properties and a dual nuclear and cytoplasmic 
      distribution. Immunohistochemical staining showed a distinct pattern of hASNA-I 
      expression in cells within normal tissues, and its overexpression in breast 
      cancer. Recently, the yeast two-hybrid system has identified hASNA-I as a 
      cellular partner of metallothionein II suggesting an additional role in Zn 
      homeostasis and cellular detoxification. This report describes the assignment of 
      hASNA-I to human chromosome 19 by somatic-cell hybrid PCR mapping, the isolation 
      of a chromosome 19-specific cosmid clone, and the genomic structure and 
      exon-intron boundaries of hASNA-I. Our results indicate that the coding region of 
      hASNA-I consists of 4 exons spanning 6 kb on band 19q13.3. These data will 
      facilitate molecular analysis of the role of hASNA-I in human disease.
FAU - Kurdi-Haidar, B
AU  - Kurdi-Haidar B
AD  - Department of Medicine, University of California San Diego, La Jolla 92093-0058, 
      USA.
FAU - Heath, D
AU  - Heath D
FAU - Lennon, G
AU  - Lennon G
FAU - Howell, S B
AU  - Howell SB
LA  - eng
GR  - R01 CA69004-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Somat Cell Mol Genet
JT  - Somatic cell and molecular genetics
JID - 8403568
RN  - 0 (Arsenites)
RN  - 0 (Enzyme Activators)
RN  - 0 (Ion Pumps)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Teratogens)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.3.16 (Arsenite Transporting ATPases)
RN  - N5509X556J (arsenite)
SB  - IM
MH  - Adenosine Triphosphatases/*genetics/metabolism
MH  - Arsenite Transporting ATPases
MH  - Arsenites/pharmacology
MH  - *Chromosome Mapping/methods
MH  - Chromosomes, Human, Pair 19/genetics
MH  - Cosmids/genetics
MH  - Enzyme Activators/pharmacology
MH  - Exons/genetics
MH  - Genomic Library
MH  - Humans
MH  - Introns/genetics
MH  - *Ion Pumps
MH  - *Multienzyme Complexes
MH  - Restriction Mapping
MH  - Teratogens/pharmacology
EDAT- 2000/03/04 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
AID - 10.1023/b:scam.0000007134.16744.8b [doi]
PST - ppublish
SO  - Somat Cell Mol Genet. 1998 Sep;24(5):307-11. doi: 
      10.1023/b:scam.0000007134.16744.8b.