PMID- 10697612
OWN - NLM
STAT- MEDLINE
DCOM- 20000310
LR  - 20071114
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 6C
DP  - 1999 Nov-Dec
TI  - 37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are 
      identical, universal T-cell inducing immunogens on primary rodent and human 
      cancers.
PG  - 5535-42
AB  - Based upon positive immunologic comparisons, protein and cDNA sequencing, and in 
      vitro and in vivo immunogenicity studies we propose that carcinomas, sarcomas and 
      lymphomas/leukemias of rodents and humans share 37 kDa Onco-Fetal Antigen [OFA] 
      as a T and B-lymphocyte stimulating, universal tumor specific transplantation 
      antigen [UTSTA]. In the past four years, biochemical studies from several 
      laboratories studying laminin receptor protein and immunological studies of OFA 
      from our laboratories independently converged. OFA protein and immature or 
      precursor Laminin Receptor Protein [iLRP] are > 99% identical proteins based on 
      amino acid and cDNA sequencing and immunobiology studies summarized here. 
      Acquired expression of 37 kDa OFA/iLRP enables malignant tumor cells to penetrate 
      laminin tissue and vessel barriers. 37 kDa OFA/iLRP activates precursor thymic 
      anti-OFA/iLRP specific cytotoxic T cell which kill emerging pretumor cells. Our 
      reported findings also demonstrate that OFA/iLRP can function to induce specific 
      immunoregulatory CD8 T-suppressor cells secreting IL-10 which impair effector 
      T-cell killing of emerging tumor cells non-specifically and thereby facilitate 
      tumor progression. Potential applications of OFA/iLRP detection in early cancer 
      formation, for monitoring patient T cell subclass responses to OFA/iLRP as a 
      predictor of tumor progression, and the use of OFA/iLRP peptides for specific 
      anti-tumor immunotherapy are presented.
FAU - Coggin, J H Jr
AU  - Coggin JH Jr
AD  - Department of Microbiology and Immunology, University of South Alabama, College 
      of Medicine, Mobile 36688-0002, USA.
FAU - Barsoum, A L
AU  - Barsoum AL
FAU - Rohrer, J W
AU  - Rohrer JW
LA  - eng
GR  - CA39698/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (DNA, Complementary)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Precursors)
RN  - 0 (Receptors, Laminin)
RN  - 0 (immature laminin receptor protein, mouse)
RN  - 0 (oncofetal antigens)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies, Monoclonal
MH  - Antibody Specificity
MH  - Antigens, Neoplasm/*chemistry/genetics/immunology
MH  - Base Sequence
MH  - Breast Neoplasms/*immunology/pathology
MH  - DNA, Complementary/analysis
MH  - Fibrosarcoma/*genetics/metabolism
MH  - Humans
MH  - Lymphocyte Activation
MH  - Mice
MH  - Molecular Sequence Data
MH  - Molecular Weight
MH  - Peptide Fragments/chemistry
MH  - Protein Precursors/*chemistry/genetics/immunology
MH  - *Receptors, Laminin
MH  - Sequence Analysis
MH  - Sequence Homology, Nucleic Acid
MH  - T-Lymphocytes/*immunology
MH  - Tumor Cells, Cultured
EDAT- 2000/03/04 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 Nov-Dec;19(6C):5535-42.