PMID- 10698154
OWN - NLM
STAT- MEDLINE
DCOM- 20000330
LR  - 20191024
IS  - 0923-1811 (Print)
IS  - 0923-1811 (Linking)
VI  - 22
IP  - 3
DP  - 2000 Apr
TI  - Virus-induced immune dysregulation as a triggering factor for the development of 
      drug rashes and autoimmune diseases: with emphasis on EB virus, human herpesvirus 
      6 and hepatitis C virus.
PG  - 169-80
AB  - There are a considerable amount of empirical and theoretic medical literature 
      regarding the possible role of viruses in the development of drug rashes and 
      autoimmune diseases: under these conditions, interactions of viruses with the 
      immune system would serve as an accelerating factor of disease pathogenesis. 
      Recent reports have provided evidence to indicate that immune responses against 
      infections with Epstein Barr (EB) virus and human herpesvirus 6 (HHV-6), which 
      are lymphotropic members of the herpes virus group, not only aid the direct 
      elimination of the virus but also contribute to a favorable milieu for the 
      initiation or acceleration of drug rashes. Viruses that can persist for the 
      lifetime of the host despite strong immune responses against them, such as EB 
      virus and hepatitis C virus (HCV), would be also relevant to the pathogenesis of 
      autoimmune diseases. HCV has been reportedly associated with a wide variety of 
      dermatoses that, in common, show histologically the lichenoid tissue reaction. 
      Although porokeratosis that manifests lichenoid histopathological features had 
      long been regarded as being associated with immunosuppression, we found that HCV 
      could act as trigger for the development of porokeratosis during states of 
      immunosuppression. Thus, the main purpose of this review is to describe recent 
      work on the etiology of drug rashes and autoimmune disease with special reference 
      to viral infections.
FAU - Mizukawa, Y
AU  - Mizukawa Y
AD  - Department of Dermatology, Kyorin University School of Medicine, Mikata-city, 
      Tokyo, Japan.
FAU - Shiohara, T
AU  - Shiohara T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
SB  - IM
MH  - Autoimmune Diseases/*etiology
MH  - Drug Eruptions/*etiology
MH  - Epstein-Barr Virus Infections/complications/immunology
MH  - Hepacivirus/*pathogenicity
MH  - Hepatitis C/complications/immunology
MH  - Herpesviridae Infections/complications/immunology
MH  - Herpesvirus 4, Human/*pathogenicity
MH  - Herpesvirus 6, Human/*pathogenicity
MH  - Humans
MH  - Porokeratosis/etiology
RF  - 75
EDAT- 2000/03/04 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
AID - S0923181199000833 [pii]
AID - 10.1016/s0923-1811(99)00083-3 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2000 Apr;22(3):169-80. doi: 10.1016/s0923-1811(99)00083-3.