PMID- 10699012
OWN - NLM
STAT- MEDLINE
DCOM- 20000405
LR  - 20200724
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 38
IP  - 3
DP  - 2000 Mar
TI  - Efficacy of antimicrobial treatments and vaccination regimens for control of 
      porcine reproductive and respiratory syndrome virus and Streptococcus suis 
      coinfection of nursery pigs.
PG  - 1156-60
AB  - Seventy-six, crossbred, porcine reproductive and respiratory syndrome virus 
      (PRRSV)-free pigs were weaned at 12 days of age and randomly assigned to seven 
      groups of 10 to 11 pigs each. Pigs in group 1 served as unchallenged controls. 
      Pigs in groups 2 to 7 were challenged intranasally with 2 ml of high-virulence 
      PRRSV isolate VR-2385 (10(4.47) 50% tissue culture infective doses per 2 ml) on 
      day 0 of the study (30 days of age). Seven days after PRRSV challenge, pigs in 
      groups 2 to 7 were challenged intranasally with 2 ml of Streptococcus suis 
      serotype 2 (10(8.30) CFU/2 ml). Group 2 pigs served as untreated positive 
      controls. Antimicrobial treatments included daily intramuscular injection with 
      66,000 IU of procaine penicillin G per kg of body weight on days 8 to 10 (group 
      3), drinking water medication with 23.1 mg of tiamulin per kg during days 8 to 10 
      (group 4), and daily intramuscular injection of 5.0 mg of ceftiofur hydrochloride 
      per kg on days 8 to 10 (group 5). Vaccination regimens included two intramuscular 
      doses of an autogenous killed S. suis vaccine (group 6) prior to S. suis 
      challenge or a single 2-ml intramuscular dose of an attenuated live PRRSV vaccine 
      (group 7) 2 weeks prior to PRRSV challenge. Mortality was 0, 63, 45, 54, 9, 40, 
      and 81% in groups 1 to 7, respectively. Ceftiofur treatment was the only regimen 
      that significantly (P < 0. 05) reduced mortality associated with PRRSV and S. 
      suis coinfection. The other treatments and vaccinations were less effective. We 
      conclude that ceftiofur administered by injection for three consecutive days 
      following S. suis challenge was the most effective regimen for minimizing disease 
      associated with PRRSV and S. suis coinfection.
FAU - Halbur, P
AU  - Halbur P
AD  - Department of Veterinary Diagnostic and Production Animal Medicine, College of 
      Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA. 
      pghalbur@iastate.edu
FAU - Thanawongnuwech, R
AU  - Thanawongnuwech R
FAU - Brown, G
AU  - Brown G
FAU - Kinyon, J
AU  - Kinyon J
FAU - Roth, J
AU  - Roth J
FAU - Thacker, E
AU  - Thacker E
FAU - Thacker, B
AU  - Thacker B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cephalosporins)
RN  - 0 (Diterpenes)
RN  - 0 (Viral Vaccines)
RN  - 17R794ESYN (Penicillin G Procaine)
RN  - 83JL932I1C (ceftiofur)
RN  - E38WZ4U54R (tiamulin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/*therapeutic use
MH  - Antibiotic Prophylaxis/*veterinary
MH  - Cephalosporins/administration & dosage/*therapeutic use
MH  - Diterpenes/administration & dosage/therapeutic use
MH  - Injections, Intramuscular
MH  - Penicillin G Procaine/administration & dosage/*therapeutic use
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/immunology/pathogenicity
MH  - Streptococcal Infections/immunology/prevention & control/*veterinary
MH  - *Streptococcus suis/immunology/pathogenicity
MH  - Swine
MH  - Swine Diseases/immunology/*prevention & control
MH  - *Viral Vaccines
MH  - Virulence
MH  - Water Supply
PMC - PMC86362
EDAT- 2000/03/04 00:00
MHDA- 2000/03/04 00:01
PMCR- 2000/03/01
CRDT- 2000/03/04 00:00
PHST- 2000/03/04 00:00 [pubmed]
PHST- 2000/03/04 00:01 [medline]
PHST- 2000/03/04 00:00 [entrez]
PHST- 2000/03/01 00:00 [pmc-release]
AID - 0901 [pii]
AID - 10.1128/JCM.38.3.1156-1160.2000 [doi]
PST - ppublish
SO  - J Clin Microbiol. 2000 Mar;38(3):1156-60. doi: 10.1128/JCM.38.3.1156-1160.2000.