PMID- 10699663
OWN - NLM
STAT- MEDLINE
DCOM- 20000503
LR  - 20191210
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 109
IP  - 1
DP  - 2000 Apr
TI  - Functional role of rat prelimbic-infralimbic cortices in spatial memory: evidence 
      for their involvement in attention and behavioural flexibility.
PG  - 113-28
AB  - The involvement of the medial prefrontal cortex (mPFC), and more particularly the 
      prelimbic and infralimbic cortices (PL-IL area), in spatial memory remains 
      controversial. The present study investigates the effects of neurotoxic lesions 
      restricted to the PL-IL area of the mPFC in rats trained in two different spatial 
      tasks. In experiment 1, PL-IL lesioned rats showed normal acquisition of a 
      delayed non-matching to position task. They were also able to plan their 
      responses for a prospective strategy but were transiently disrupted when the 
      initial delay was extended. In experiment 2, rats were trained to locate one 
      baited box among 13 identical boxes distributed on a circular arena. Lesioned 
      rats performed normally when trained from a single start position but were 
      severely disrupted when four start positions were used. A probe trial showed this 
      deficit was not due to failure to learn the goal location. The addition of a 
      proximal cue signalling the goal box helped lesioned rats to directly open the 
      goal box, but did not compensate for greater distances that they travelled to 
      reach it. Results from both experiments indicate that the PL-IL area is directly 
      involved neither in allocentric spatial representations nor prospective memory 
      and is not specifically involved in working memory. This area seems more likely 
      to be involved in both attentional processes and behavioural flexibility that may 
      be important for processing information for working memory as well as for spatial 
      memory.
FAU - Delatour, B
AU  - Delatour B
AD  - Laboratoire de Neurobiologie de l'Apprentissage, de la Memoire et de la 
      Communication (NAMC), CNRS-UMR 8620, Universite Paris-Sud, Bat. 446, 91405, 
      Orsay, France.
FAU - Gisquet-Verrier, P
AU  - Gisquet-Verrier P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Animals
MH  - Attention/*physiology
MH  - Brain Mapping
MH  - Cues
MH  - Discrimination Learning/physiology
MH  - Limbic System/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Mental Recall/*physiology
MH  - Orientation/*physiology
MH  - Prefrontal Cortex/*physiology
MH  - Problem Solving/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Retention, Psychology/physiology
EDAT- 2000/03/04 09:00
MHDA- 2000/05/08 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
AID - S0166-4328(99)00168-0 [pii]
AID - 10.1016/s0166-4328(99)00168-0 [doi]
PST - ppublish
SO  - Behav Brain Res. 2000 Apr;109(1):113-28. doi: 10.1016/s0166-4328(99)00168-0.