PMID- 10700337
OWN - NLM
STAT- Publisher
LR  - 20220317
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 3
IP  - 1
DP  - 1999 Mar
TI  - PET study on central processing of pain in trigeminal neuropathy.
PG  - 51-65
AB  - Recent functional brain imaging studies with positron emission tomography (PET), 
      in painful peripheral mononeuropathy and nitroglycerin-provoked cluster headache 
      attacks, suggest a preference of the right hemisphere, especially the anterior 
      cingulate cortex (ACC) and the medial prefrontal cortex (MPFC), in attributing 
      emotional valence and attention to the pain suffering. We have investigated the 
      central processing of painful trigeminal neuropathy (PTN) in patients treated 
      with electric extradural precentral gyrus stimulation (PCGS). Increased regional 
      cerebral blood flow (rCBF) was detected in the right caudal ACC [Brodmann area 
      (BA) 24] and anterior limbic thalamus, while a decreased activity was observed in 
      the right MPFC (BA 9/32) during the habitual-pain state, in comparison with the 
      pain-alleviated state regardless of the inflicted side of PTN. The involvement of 
      BA 9/32 and the anterior limbic thalamus spatially extended to the left 
      hemisphere, but the local maxima and a significant negative correlation between 
      the rCBF changes in the two structures were found only in the right hemisphere. 
      The activation of the caudal BA24 further supports the theory that ACC is crucial 
      for the suffering in chronic pain. Our study not only verifies the preferential 
      role of the right hemisphere in the appreciation of pain suffering, but further 
      supports that sustained chronic pain, being devoid of the motivational component 
      of an escape response, targets the right hemisphere, particularly the BA24 of the 
      ACC. Copyright 1999 European Federation of Chapters of the International 
      Association for the Study of Pain.
FAU - Hsieh, JC
AU  - Hsieh JC
AD  - PET Cognitive Neurophysiology, Department of Clinical Neuroscience, Karolinska 
      Hospital/Karolinska Institute, Stockholm, S-17176, Sweden
FAU - Meyerson, BA
AU  - Meyerson BA
FAU - Ingvar, M
AU  - Ingvar M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
EDAT- 2000/03/04 00:00
MHDA- 2000/03/04 00:00
CRDT- 2000/03/04 00:00
PHST- 2000/03/04 00:00 [pubmed]
PHST- 2000/03/04 00:00 [medline]
PHST- 2000/03/04 00:00 [entrez]
AID - eujp.1998.0101 [pii]
AID - 10.1053/eujp.1998.0101 [doi]
PST - ppublish
SO  - Eur J Pain. 1999 Mar;3(1):51-65. doi: 10.1053/eujp.1998.0101.