PMID- 10700558
OWN - NLM
STAT- MEDLINE
DCOM- 20000504
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 857
IP  - 1-2
DP  - 2000 Feb 28
TI  - Effects of prolactin on expression of Fos-related antigens in tyrosine 
      hydroxylase-immunoreactive neurons in subdivisions of the arcuate nucleus.
PG  - 110-8
AB  - Dual immunohistochemistry was employed to determine the effects of prolactin on 
      expression of Fos and its related antigens (FRA) in tuberoinfundibular dopamine 
      (TIDA) neurons located in the dorsomedial (DM) and ventrolateral (VL) 
      subdivisions of the arcuate nucleus (ARC) in the male rat. Systemic 
      administration of the DA receptor antagonist haloperidol caused a sustained (up 
      to 12 h) increase in plasma prolactin concentrations that was accompanied by a 
      transient increase (at 3 h) in the percentage of tyrosine hydroxylase 
      (TH)-immunoreactive (IR) neurons containing FRA-IR nuclei in the DM-ARC. In 
      contrast, haloperidol caused a prolonged (1. 5 to 12 h) decrease in the 
      percentage of TH-IR neurons with FRA-IR nuclei in the VL-ARC. Haloperidol had no 
      effect, however, on the overall number of TH-IR neurons in either of these 
      regions. Co-administration of prolactin antisera (PRL-AB) blocked 
      haloperidol-induced increases in both plasma prolactin concentrations and the 
      percentage of TH-IR neurons expressing FRA in the DM-ARC, but had no effect on 
      haloperidol-induced inhibition of FRA expression in TH-IR neurons in the VL-ARC. 
      Intracerebroventricular (i.c.v.) administration of prolactin also increased the 
      percentage of TH-IR neurons containing FRA-IR nuclei in the DM-ARC, but this 
      effect was of longer duration (up to 6 h) than that of haloperidol in all but the 
      most caudal portion of the DM-ARC. In the VL-ARC, prolactin caused a transient 
      increase (at 1.5 h) in the percentage of TH-IR containing FRA-IR nuclei. These 
      results demonstrate that prolactin regulates immediate early gene expression in 
      TIDA neurons in male rats, and reveal that there are temporal differences in the 
      responsiveness of discrete subpopulations of these neurons to prolactin. 
      Prolactin causes a short-lived increase in FRA expression in TIDA neurons in the 
      VL-ARC which is followed by a more prolonged activation of FRA expression in TIDA 
      neurons in the DM-ARC.
FAU - Hentschel, K
AU  - Hentschel K
AD  - Department of Pharmacology and Toxicology, Michigan State University, B-432 Life 
      Sciences Bldg., East Lansing, MI 48824-1317, USA.
FAU - Moore, K E
AU  - Moore KE
FAU - Lookingland, K J
AU  - Lookingland KJ
LA  - eng
GR  - MH42802/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 9002-62-4 (Prolactin)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - J6292F8L3D (Haloperidol)
SB  - IM
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/cytology/*drug effects/*metabolism
MH  - Dopamine Antagonists/pharmacology
MH  - Haloperidol/pharmacology
MH  - Male
MH  - Neurons/*drug effects/*metabolism
MH  - Prolactin/drug effects/*metabolism/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/*drug effects/*metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Time Factors
MH  - Tyrosine 3-Monooxygenase/*analysis
EDAT- 2000/03/04 09:00
MHDA- 2000/05/08 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
AID - S0006-8993(99)02362-8 [pii]
AID - 10.1016/s0006-8993(99)02362-8 [doi]
PST - ppublish
SO  - Brain Res. 2000 Feb 28;857(1-2):110-8. doi: 10.1016/s0006-8993(99)02362-8.