PMID- 10700591
OWN - NLM
STAT- MEDLINE
DCOM- 20000425
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 858
IP  - 1
DP  - 2000 Mar 6
TI  - A novel action of the newly described prolactin-releasing peptides: 
      cardiovascular regulation.
PG  - 19-25
AB  - The physiological relevance of the recently described prolactin-releasing 
      peptides (PrRPs) has yet to be established. Here, we demonstrate the low potency 
      of the PrRPs (minimum effective dose: 100 nM), compared to that observed for 
      thyrotropin-releasing hormone (TRH, minimum effective dose: 1.0 nM), to stimulate 
      prolactin (PRL) release from cultured pituitary cells harvested from lactating 
      female rats. Anatomic studies question the role of these peptides in 
      neuroendocrine control of lactotroph function. Instead, peptide and peptide 
      receptor mapping studies suggest potential actions in hypothalamus and brainstem 
      unrelated to the control of anterior pituitary hormone secretion. 
      Intracerebroventricular (i.c.v. ) administration of both PrRP-20 and PrRP-31 (0.4 
      and 4.0 nmol) resulted in significantly increased mean arterial blood pressure in 
      conscious, unrestrained rats [peak elevations vs. baseline: PrRP-20, 10% and 16%, 
      low and high dose peptide; PrRP-31, 7% and 10%; compared to the response to 0.1 
      nmol angiotensin II (A II), 15-17%]. Similar doses of peptide did not 
      significantly alter water drinking in response to overnight fluid deprivation, or 
      thirst or salt appetite in response to an isotonic hypovolemic challenge. Thus, 
      the effect on blood pressure appeared relatively specific. We suggest that these 
      peptides, identified originally as ligands for a receptor found in abundance in 
      pituitary gland, play a broader role in brain function and that the ability of 
      them to stimulate PRL release may not represent their primary biologic function.
FAU - Samson, W K
AU  - Samson WK
AD  - Department of Pharmacological and Physiological Sciences, St. Louis University 
      School of Medicine, St. Louis, MO 63104-1028, USA. samsonwk@slu.edu
FAU - Resch, Z T
AU  - Resch ZT
FAU - Murphy, T C
AU  - Murphy TC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hypothalamic Hormones)
RN  - 0 (Neuropeptides)
RN  - 0 (Prlh protein, rat)
RN  - 0 (Prolactin-Releasing Hormone)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 11128-99-7 (Angiotensin II)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Angiotensin II/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - *Cardiovascular Physiological Phenomena/drug effects
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Drinking Behavior/drug effects
MH  - Female
MH  - Hypothalamic Hormones/administration & dosage/*physiology
MH  - Injections, Intraventricular
MH  - Lactation/metabolism
MH  - Male
MH  - Neuropeptides/administration & dosage/*physiology
MH  - Pituitary Gland, Anterior/cytology/metabolism
MH  - Prolactin/biosynthesis
MH  - Prolactin-Releasing Hormone
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sodium Chloride, Dietary
MH  - Thyrotropin-Releasing Hormone/pharmacology
MH  - Water Deprivation/physiology
EDAT- 2000/03/04 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
AID - S0006-8993(99)02451-8 [pii]
AID - 10.1016/s0006-8993(99)02451-8 [doi]
PST - ppublish
SO  - Brain Res. 2000 Mar 6;858(1):19-25. doi: 10.1016/s0006-8993(99)02451-8.