PMID- 10700868
OWN - NLM
STAT- MEDLINE
DCOM- 20000316
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 117
IP  - 1
DP  - 2000 Feb
TI  - Multiple myeloma: monoallelic deletions of the tumor suppressor genes TP53 and 
      RB1 in long-term follow-up.
PG  - 57-60
AB  - Recently, a working-model of a stepwise malignant transformation in the molecular 
      pathogenesis of multiple myeloma (MM) was proposed, involving the tumor 
      suppressor gene TP53 and retinoblastoma gene (RB1) as prominent components of 
      cell cycle control. To further define the role of TP53 and RB1 in disease 
      progression, we retrospectively analyzed by fluorescence in situ hybridization 
      (FISH) cytological material from 16 patients who underwent sequential bone marrow 
      biopsies during the course of their disease. For TP53, no deletions were detected 
      at presentation or during follow-up. It is possible that the patients reported 
      here represent a subset with relatively long survival, and therefore did not 
      demonstrate the TP53 deletions that had been reported in patients with a very 
      poor prognosis. For RB1, monoallelic deletion was demonstrated in nine patients. 
      In each case, the deletion appeared already in the first biopsy analyzed. The 
      presence of a deletion did not affect the rate of tumor progression or the length 
      of follow-up, and thus prognosis. Monoallelic deletions of RB1 appear to be a 
      frequent and early event in the pathogenesis of MM, without obvious relevance for 
      disease progression.
FAU - Carlebach, M
AU  - Carlebach M
AD  - Department of Medicine, Meir Hospital, Kfar Saba, Israel.
FAU - Amiel, A
AU  - Amiel A
FAU - Gaber, E
AU  - Gaber E
FAU - Radnay, J
AU  - Radnay J
FAU - Manor, Y
AU  - Manor Y
FAU - Fejgin, M
AU  - Fejgin M
FAU - Lishner, M
AU  - Lishner M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Biopsy
MH  - Bone Marrow/pathology
MH  - Female
MH  - *Gene Deletion
MH  - *Genes, Retinoblastoma
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/pathology
MH  - Retrospective Studies
MH  - Tumor Suppressor Protein p53/*genetics
EDAT- 2000/03/04 09:00
MHDA- 2000/03/18 09:00
CRDT- 2000/03/04 09:00
PHST- 2000/03/04 09:00 [pubmed]
PHST- 2000/03/18 09:00 [medline]
PHST- 2000/03/04 09:00 [entrez]
AID - S0165-4608(99)00144-2 [pii]
AID - 10.1016/s0165-4608(99)00144-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Feb;117(1):57-60. doi: 
      10.1016/s0165-4608(99)00144-2.