PMID- 10702681
OWN - NLM
STAT- MEDLINE
DCOM- 20000412
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 87
IP  - 3-4
DP  - 1999
TI  - Identification and chromosomal localization of murine ORC3, a new member of the 
      mouse origin recognition complex.
PG  - 245-51
AB  - A new member of the murine origin recognition complex (ORC) related to 
      Saccharomyces cerevisiae ORC3 has been cloned. Transcription of ORC3 is not 
      suppressed in mouse NIH3T3 fibroblasts made quiescent by serum starvation. The 
      transcription level of the ORC3 gene is constantly high in all phases of the cell 
      cycle. Murine ORC3 protein contains a putative nuclear localization signal and a 
      non-basic helix-loop-helix motif. Both motifs are conserved in eukaryotes. A 
      potential dimerization partner of ORC3p in the murine ORC complex is ORC1p which 
      also contains an HLH motif. This HLH motif is also highly conserved in all 
      eukaryotic ORC1 proteins. Comparison of murine ORC3p with other ORC3-related 
      proteins shows high amino acid homology and motif conservation leading to the 
      conclusion that ORC3p is part of the initiation machinery conserved in 
      eukaryotes. The mouse ORC3 gene Orc3 was assigned to mouse chromosome 4A3 by 
      fluorescence in situ hybridization (FISH) analysis.
CI  - Copyright 2000 S. Karger AG, Basel
FAU - Springer, J
AU  - Springer J
AD  - Institute of Biochemistry, Biozentrum, University of Wurzburg, Wurzburg, Germany.
FAU - Nanda, I
AU  - Nanda I
FAU - Hoehn, K
AU  - Hoehn K
FAU - Schmid, M
AU  - Schmid M
FAU - Grummt, F
AU  - Grummt F
LA  - eng
SI  - GENBANK/AJ132830
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Fungal Proteins)
RN  - 0 (ORC3 protein, human)
RN  - 0 (Orc1 protein, mouse)
RN  - 0 (Orc3 protein, mouse)
RN  - 0 (Origin Recognition Complex)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - 3T3 Cells
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Cycle
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins/chemistry/*genetics
MH  - Fungal Proteins/chemistry/genetics
MH  - Helix-Loop-Helix Motifs/physiology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Molecular Sequence Data
MH  - Origin Recognition Complex
MH  - *Physical Chromosome Mapping
MH  - RNA, Messenger/analysis/genetics
MH  - Replication Origin/genetics/physiology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
EDAT- 2000/03/07 09:00
MHDA- 2000/04/15 09:00
CRDT- 2000/03/07 09:00
PHST- 2000/03/07 09:00 [pubmed]
PHST- 2000/04/15 09:00 [medline]
PHST- 2000/03/07 09:00 [entrez]
AID - 15435 [pii]
AID - 10.1159/000015435 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1999;87(3-4):245-51. doi: 10.1159/000015435.