PMID- 10704490
OWN - NLM
STAT- MEDLINE
DCOM- 20000403
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 6
DP  - 2000 Mar 15
TI  - Effects of neurotrophins on cortical plasticity: same or different?
PG  - 2155-65
AB  - Neurotrophins are important regulators of visual cortical plasticity. It is still 
      unclear, however, whether they play similar or different roles and which are 
      their effects on the electrical activity of cortical neurons in vivo. We 
      therefore compared the effects of all neurotrophins, nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and 
      neurotrophin-3 (NT-3) on visual cortical plasticity and on cell spontaneous and 
      visually evoked activity. Rats were monocularly deprived for 1 week at the peak 
      of the critical period, and neurotrophins were infused intracortically. The main 
      finding is that, with the exception of NT-3, all neurotrophins affect the outcome 
      of monocular deprivation, but there are clear differences in their mechanisms of 
      action. In particular, NT-4 and NGF counteract monocular deprivation effects 
      without causing detectable alterations either in spontaneous or visually evoked 
      neuronal activity. BDNF is less effective on ocular dominance plasticity and, in 
      addition, strongly affects spontaneous and visually evoked activity in cortical 
      neurons.
FAU - Lodovichi, C
AU  - Lodovichi C
AD  - Scuola di Studi Superiori Sant'Anna, 56126 Pisa, Italy. lodovica@in.pi.cnr.it
FAU - Berardi, N
AU  - Berardi N
FAU - Pizzorusso, T
AU  - Pizzorusso T
FAU - Maffei, L
AU  - Maffei L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Electric Conductivity
MH  - Evoked Potentials, Visual/drug effects/physiology
MH  - Form Perception/drug effects/physiology
MH  - Nerve Growth Factor/pharmacology
MH  - Nerve Growth Factors/*pharmacology
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/drug effects/physiology
MH  - Neuroprotective Agents/pharmacology
MH  - Neurotrophin 3/pharmacology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Synaptic Transmission/drug effects
MH  - Vision, Monocular
MH  - Visual Cortex/*cytology/*drug effects
MH  - Visual Fields/drug effects/physiology
MH  - Visual Pathways
PMC - PMC6772512
EDAT- 2000/03/08 00:00
MHDA- 2000/03/08 00:01
PMCR- 2000/09/15
CRDT- 2000/03/08 00:00
PHST- 2000/03/08 00:00 [pubmed]
PHST- 2000/03/08 00:01 [medline]
PHST- 2000/03/08 00:00 [entrez]
PHST- 2000/09/15 00:00 [pmc-release]
AID - 4001 [pii]
AID - 10.1523/JNEUROSCI.20-06-02155.2000 [doi]
PST - ppublish
SO  - J Neurosci. 2000 Mar 15;20(6):2155-65. doi: 10.1523/JNEUROSCI.20-06-02155.2000.