PMID- 10704677
OWN - NLM
STAT- MEDLINE
DCOM- 20000317
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 117
IP  - 2
DP  - 2000 Mar
TI  - Genetic alterations of gastric cancer: comparative genomic hybridization and 
      fluorescence In situ hybridization studies.
PG  - 97-103
AB  - Genetic changes leading to the development of gastric cancers are still in 
      dispute. In the following study, we used comparative genomic hybridization (CGH) 
      to screen for DNA copy number changes along all chromosomes in 37 gastric 
      carcinomas, and fluorescence in situ hybridization (FISH) with the C-MYC and TP53 
      probes in 14 cases for comparison. The aim of this study was to identify those 
      chromosome regions that contain genes important for the development of gastric 
      carcinomas and to identify genetic markers associated with tumor progression. The 
      most often involved gains were 2q, 7pq, 8pq, 13q, 17q, 18q, and 20pq. The most 
      commonly deleted regions were 17p. The pattern of genetic changes was different 
      depending on the existence of nodal metastasis and histologic types. Gains in 8q 
      and losses in 17p were the most common features of the CGH changes. However, only 
      3 among the available 10 cases (30%) showed an amplification of the C-MYC gene by 
      FISH. Allelic loss of TP53 was found in 2 of 4 cases (50%). This difference might 
      be due to another rearrangement of these 2 genes which cannot be detected by 
      FISH, or other possible genes in that area may be involved in the tumorigenesis 
      and nodal metastasis of gastric carcinomas.
FAU - Koo, S H
AU  - Koo SH
AD  - Department of Clinical Pathology, Chungnam National University Hospital, Taejon, 
      South Korea.
FAU - Kwon, K C
AU  - Kwon KC
FAU - Shin, S Y
AU  - Shin SY
FAU - Jeon, Y M
AU  - Jeon YM
FAU - Park, J W
AU  - Park JW
FAU - Kim, S H
AU  - Kim SH
FAU - Noh, S M
AU  - Noh SM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adenocarcinoma/genetics/pathology
MH  - Adult
MH  - *Chromosome Aberrations
MH  - DNA/analysis
MH  - Female
MH  - Gene Amplification
MH  - Genes, myc
MH  - Genes, p53
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Nucleic Acid Hybridization
MH  - Stomach Neoplasms/*genetics/pathology
EDAT- 2000/03/08 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/03/08 09:00
PHST- 2000/03/08 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/03/08 09:00 [entrez]
AID - S0165-4608(99)00152-1 [pii]
AID - 10.1016/s0165-4608(99)00152-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Mar;117(2):97-103. doi: 
      10.1016/s0165-4608(99)00152-1.