PMID- 10706464
OWN - NLM
STAT- MEDLINE
DCOM- 20000324
LR  - 20190116
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 35
IP  - 3-4
DP  - 1999 Oct
TI  - Successful treatment of immunoblastic lymphadenopathy-like T-cell lymphoma with 
      cyclosporin A.
PG  - 389-95
AB  - Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is considered to belong 
      to peripheral T-cell lymphoma. Its prognosis is grave and effective treatments 
      have not been established. Recently, we gave oral cyclosporin A (CsA) to a 
      patient with IBL-like T-cell lymphoma, and succeeded in achieving dramatic 
      remission. In this case, serum levels of interleukin-12 (IL-12) and tumor 
      necrosis factor-alpha (TNF alpha) were elevated and decreased or returned to 
      normal after achieving remission. Since CsA is a potent suppressor of the immune 
      system and most notably T-cells, the immunosuppression of T-cell function might 
      have played an important role in achieving remission in this case, although the 
      precise mechanism still remains to be elucidated. The present case indicates that 
      administration of CsA may be a very effective and safe selection of therapy for 
      IBL-like T-cell lymphoma, as well as analogous disorders such as IBL and 
      angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), thereby will 
      contribute to improving the prognosis of patients with these diseases.
FAU - Takemori, N
AU  - Takemori N
AD  - Department of Internal Medicine, Asahikawa Kosei General Hospital, Japan.
FAU - Kodaira, J
AU  - Kodaira J
FAU - Toyoshima, N
AU  - Toyoshima N
FAU - Sato, T
AU  - Sato T
FAU - Sakurai, H
AU  - Sakurai H
FAU - Akakura, N
AU  - Akakura N
FAU - Kimura, S
AU  - Kimura S
FAU - Katagiri, M
AU  - Katagiri M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Administration, Oral
MH  - Aged
MH  - Cyclosporine/*administration & dosage
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/*administration & dosage
MH  - Lymphoma, T-Cell/*drug therapy/physiopathology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy/physiopathology
MH  - Remission Induction
EDAT- 2000/03/08 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/08 09:00
PHST- 2000/03/08 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/08 09:00 [entrez]
AID - 10.3109/10428199909145744 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 1999 Oct;35(3-4):389-95. doi: 10.3109/10428199909145744.