PMID- 10707794
OWN - NLM
STAT- MEDLINE
DCOM- 20000330
LR  - 20211203
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 11 Suppl 1
DP  - 2000
TI  - The ATM gene in the pathogenesis of mantle-cell lymphoma.
PG  - 127-30
AB  - BACKGROUND: Mantle-cell lymphoma (MCL) is genetically characterized by the 
      translocation t(11;14)(q13;q32) leading to an overexpression of cyclin-D1, but 
      additional chromosomal abnormalities appear to be required for MCL pathogenesis. 
      PATIENTS AND METHODS: Deletions involving chromosome 11q, which were recently 
      found as recurrent aberrations in MCL, were analyzed at the molecular level in a 
      series of 81 MCL by fluorescence in situ hybridization (FISH) with probes from a 
      contiguous set of yeast artificial chromosomes (YACs) spanning bands 11q14-q24. 
      RESULTS AND CONCLUSIONS: Loss of chromosome 11 material was observed in 37 of the 
      81 MCL cases (46%). The consensus deletion comprised YAC 801e11 containing the 
      ATM gene. The minimal region of loss was further narrowed with P1-derived 
      artificial chromosome (PAC) probes. This allowed the identification of a deletion 
      confined to the genomic region of ATM, which, together with intragenic mutations 
      found in the coding sequence, suggests a role of ATM as a tumor suppressor gene 
      in MCL.
FAU - Stilgenbauer, S
AU  - Stilgenbauer S
AD  - Abteilung Innere Medizin III, University of Ulm, Germany.
FAU - Schaffner, C
AU  - Schaffner C
FAU - Winkler, D
AU  - Winkler D
FAU - Ott, G
AU  - Ott G
FAU - Leupolt, E
AU  - Leupolt E
FAU - Bentz, M
AU  - Bentz M
FAU - Moller, P
AU  - Moller P
FAU - Muller-Hermelink, H K
AU  - Muller-Hermelink HK
FAU - James, M R
AU  - James MR
FAU - Lichter, P
AU  - Lichter P
FAU - Dohner, H
AU  - Dohner H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (ATM protein, human)
RN  - EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Ataxia Telangiectasia Mutated Proteins
MH  - Cell Cycle Proteins
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 11
MH  - DNA-Binding Proteins
MH  - Female
MH  - *Genes, bcl-1
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Mantle-Cell/*genetics/physiopathology
MH  - Male
MH  - Protein Serine-Threonine Kinases/*genetics
MH  - Sensitivity and Specificity
MH  - Translocation, Genetic
MH  - Tumor Suppressor Proteins
EDAT- 2000/03/09 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/09 09:00
PHST- 2000/03/09 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/09 09:00 [entrez]
PST - ppublish
SO  - Ann Oncol. 2000;11 Suppl 1:127-30.