PMID- 10707980
OWN - NLM
STAT- MEDLINE
DCOM- 20000323
LR  - 20190822
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 25
IP  - 1
DP  - 2000 Jan
TI  - Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation.
PG  - 151-63
AB  - The role of the target cell in neurotrophin-induced modifications of 
      glutamatergic synaptic transmission was examined in cultured hippocampal neurons. 
      Brain-derived neurotrophic factor (BDNF) induced rapid and persistent 
      potentiation of evoked glutamate release when the postsynaptic neuron was 
      glutamatergic, or excitatory (E-->E), but not when it was GABAergic, or 
      inhibitory (E-->1). This target-specific action of BDNF was also found at 
      divergent outputs of a single presynaptic neuron innervating both glutamatergic 
      and GABAergic neurons, suggesting that individual terminals can be independently 
      modified. Surprisingly, BDNF increased the frequency of miniature postsynaptic 
      currents at both E-->E and E-->I, although it had no effect on evoked currents at 
      E-->I. Finally, potentiation by neurotrophin-3 (NT-3) was also target specific. 
      The selective effect at E-->E suggests that retrograde signaling by the 
      postsynaptic target cell endows a localized presynaptic action of neurotrophins.
FAU - Schinder, A F
AU  - Schinder AF
AD  - Department of Biology, University of California, San Diego, La Jolla 92093, USA.
FAU - Berninger, B
AU  - Berninger B
FAU - Poo, M
AU  - Poo M
LA  - eng
GR  - NS37831/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - Glutamic Acid/metabolism
MH  - Neural Inhibition/drug effects/physiology
MH  - Neuronal Plasticity/physiology
MH  - Neurotrophin 3/pharmacology
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Synaptic Membranes/chemistry/*drug effects/*physiology
MH  - Synaptic Transmission/*drug effects/*physiology
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 2000/03/09 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/03/09 09:00
PHST- 2000/03/09 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/03/09 09:00 [entrez]
AID - S0896-6273(00)80879-X [pii]
AID - 10.1016/s0896-6273(00)80879-x [doi]
PST - ppublish
SO  - Neuron. 2000 Jan;25(1):151-63. doi: 10.1016/s0896-6273(00)80879-x.