PMID- 10708589
OWN - NLM
STAT- MEDLINE
DCOM- 20000419
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 269
IP  - 2
DP  - 2000 Mar 16
TI  - Association of estrogen receptor beta gene polymorphism with bone mineral 
      density.
PG  - 537-41
AB  - Chromosomal mapping of the human estrogen receptor beta (ERbeta) gene by 
      fluorescence in situ hybridization (FISH) reveals that ERbeta is located at human 
      chromosome 14, region q23-24.1, where the aberration of DNA copy number in the 
      bone disorders is frequently involved. Then, we investigated the association 
      between dinucleotide (cytosine-adenine; CA) repeat polymorphism located in the 
      flanking region of ERbeta gene and bone mineral density (BMD) in 204 healthy 
      postmenopausal Japanese women. The genotype was classified into "A" through "O" 
      according to the number of the repeats, from 18 to 32. BMD was expressed in Z 
      score (a deviation from the weight-adjusted average BMD of each age using the 
      standard deviation as a unit). When we separate the subjects into two groups 
      bearing at least one I allele (26 CA repeats) and those who did not, the former 
      subjects had significantly higher Z score of L2-4 BMD (mean +/- standard 
      deviation; 0.674 +/- 1.53 vs 0.128 +/- 1.38; P = 0.027). These data suggest that 
      genetic variation at the ERbeta locus may be associated with some determinants 
      for BMD and the possible involvements of this polymorphism in the cause of 
      postmenopausal osteoporosis in Japanese women.
CI  - Copyright 2000 Academic Press.
FAU - Ogawa, S
AU  - Ogawa S
AD  - Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo, 
      7-3-1, Hongo, Bunkyo-ku, Tokyo, 113, Japan.
FAU - Hosoi, T
AU  - Hosoi T
FAU - Shiraki, M
AU  - Shiraki M
FAU - Orimo, H
AU  - Orimo H
FAU - Emi, M
AU  - Emi M
FAU - Muramatsu, M
AU  - Muramatsu M
FAU - Ouchi, Y
AU  - Ouchi Y
FAU - Inoue, S
AU  - Inoue S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA Primers)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Base Sequence
MH  - *Bone Density
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 14
MH  - DNA Primers
MH  - Estrogen Receptor beta
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Microsatellite Repeats/genetics
MH  - *Polymorphism, Genetic
MH  - Postmenopause
MH  - Receptors, Estrogen/*genetics
EDAT- 2000/03/10 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/03/10 09:00
PHST- 2000/03/10 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/03/10 09:00 [entrez]
AID - S0006-291X(00)92285-X [pii]
AID - 10.1006/bbrc.2000.2285 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Mar 16;269(2):537-41. doi: 
      10.1006/bbrc.2000.2285.