PMID- 10712310
OWN - NLM
STAT- MEDLINE
DCOM- 20000425
LR  - 20061115
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 161
IP  - 3 Pt 1
DP  - 2000 Mar
TI  - Association study of the chromosomal region containing the FCER2 gene suggests it 
      has a regulatory role in atopic disorders.
PG  - 700-6
AB  - On the basis of studies with animal models, the gene for the low-affinity 
      receptor for immunoglobulin E (IgE) (FCER2, CD23) has been implicated as a 
      candidate for IgE-mediated allergic diseases and bronchial hyperreactivity, or 
      related traits. Given evidence for genetic complexity in atopic disorders, we 
      sought to study two European subpopulations, Finnish and Catalonian. We studied 
      three phenotypic markers: (1) total serum IgE level; (2) asthma; and (3) specific 
      IgE level for a mixture of the most common aeroallergens in Finland. Altogether, 
      eight polymorphic markers spanning a region of 10 cM around the FCER2 gene on 
      chromosome 19p13 were analyzed in 124 families. The physical order of the markers 
      and the location of the FCER2 gene were confirmed by using radiation hybrids. The 
      allele and haplotype association study showed a suggestive haplotype association 
      (significance of p </= 0.03 based on a permutation test) for a high serum IgE 
      response. In a subset of chromosomes segregating with asthma in families with two 
      or more affected members, a single haplotype was found to be highly enriched (p = 
      8.3 x 10(-6)). However, sequence polymorphisms, which would verify structural 
      differences in the FCER2 gene, were not detected in the coding region of the 
      receptor. Our results suggest that chromosome 19p13 might harbor a genetic 
      determinant of IgE-related traits. Studies in other population samples are needed 
      to verify this finding.
FAU - Laitinen, T
AU  - Laitinen T
AD  - Department of Medical Genetics, Haartman Institute, University of Helsinki, 
      Helsinki, Finland. tarja.laitinen@helsinki.fi
FAU - Ollikainen, V
AU  - Ollikainen V
FAU - Lazaro, C
AU  - Lazaro C
FAU - Kauppi, P
AU  - Kauppi P
FAU - de Cid, R
AU  - de Cid R
FAU - Anto, J M
AU  - Anto JM
FAU - Estivill, X
AU  - Estivill X
FAU - Lokki, H
AU  - Lokki H
FAU - Mannila, H
AU  - Mannila H
FAU - Laitinen, L A
AU  - Laitinen LA
FAU - Kere, J
AU  - Kere J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Genetic Markers)
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Asthma/*genetics/immunology
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - Cross-Cultural Comparison
MH  - Female
MH  - Finland
MH  - Genes, Regulator/*genetics
MH  - Genetic Markers/genetics
MH  - Genetics, Population
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/genetics
MH  - Receptors, IgE/*genetics
MH  - Respiratory Hypersensitivity/*genetics/immunology
MH  - Spain
EDAT- 2000/03/11 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/03/11 09:00
PHST- 2000/03/11 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/11 09:00 [entrez]
AID - 10.1164/ajrccm.161.3.9810056 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):700-6. doi: 
      10.1164/ajrccm.161.3.9810056.