PMID- 10712327
OWN - NLM
STAT- MEDLINE
DCOM- 20000425
LR  - 20141120
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 161
IP  - 3 Pt 1
DP  - 2000 Mar
TI  - Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical 
      features of pulmonary sarcoidosis.
PG  - 814-8
AB  - In previous reports of studies of Scandinavian sarcoidosis patients, we have 
      described a strong association between lung-restricted expansions of T cells 
      expressing T-cell receptor (TCR) AV2S3 and the human leukocyte antigen 
      (HLA)-DRB1*0301 (DR17) and -DRB3*0101 alleles, suggesting the presence of a 
      specific antigen in sarcoidosis. In the present study, the degree of 
      lung-accumulated TCR AV2S3(+) T cells was related to clinical data in 51 
      HLA-DRB1*0301/DRB3*0101-positive Scandinavian patients with pulmonary 
      sarcoidosis. Significantly more AV2S3(+) lung T cells (median: 30.0% of CD4(+) 
      cells in bronchoalveolar lavage fluid [BALF]) were found accumulated in patients 
      with a short (< 2 yr) than with a long (> 2 yr) (median: 18.6%) disease duration 
      (p = 0.003). A strong positive association was also found between lung-restricted 
      AV2S3(+) T cells and both the CD4(+)-to-CD8(+) cell ratio (p = 7 x 10(-6)) in 
      BALF and with an acute disease onset (p = 0.018). Negative associations were 
      found between both the interval from disease onset to bronchoalveolar lavage (p = 
      0.0001) and the age of the patient (p = 0.002). Our findings strongly link 
      lung-accumulated AV2S3(+) T cells to the acute inflammatory response in 
      sarcoidosis. Moreover, the association of these cells with a good prognosis 
      indicates that AV2S3(+) T cells may have a protective role against a presumed 
      sarcoidosis antigen.
FAU - Grunewald, J
AU  - Grunewald J
AD  - Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, 
      Stockholm, Sweden. johan.grunewald@mtc.ki.se
FAU - Berlin, M
AU  - Berlin M
FAU - Olerup, O
AU  - Olerup O
FAU - Eklund, A
AU  - Eklund A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - CD4 Lymphocyte Count
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Receptors, Antigen, T-Cell/*genetics
MH  - Sarcoidosis, Pulmonary/genetics/*immunology
MH  - Scandinavian and Nordic Countries
MH  - T-Lymphocytes, Helper-Inducer/*immunology
EDAT- 2000/03/11 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/03/11 09:00
PHST- 2000/03/11 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/11 09:00 [entrez]
AID - 10.1164/ajrccm.161.3.9906001 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):814-8. doi: 
      10.1164/ajrccm.161.3.9906001.