PMID- 10713242
OWN - NLM
STAT- MEDLINE
DCOM- 20000421
LR  - 20220309
IS  - 0886-3350 (Print)
IS  - 0886-3350 (Linking)
VI  - 26
IP  - 3
DP  - 2000 Mar
TI  - Wound healing after photorefractive keratectomy.
PG  - 432-47
AB  - For more than 15 years, the excimer laser has been used as a surgical instrument 
      on the cornea. Photorefractive keratectomy (PRK) followed radial keratotomy as 
      researchers sought a more precise technique. In PRK, precision turned out to 
      depend on surgical technique as well as the wound-healing process, with the 2 
      factors interdependent. The PRK technique has evolved toward a large diameter, 
      flat ablation curvatures, and an even surface. The role of such factors as 
      cytokines and interleukins has become more clear in the past 10 years. However, 
      understanding the wound-healing process becomes more complicated with increasing 
      know edge. Learning the contributing factors and performing trials with new drugs 
      and antibodies to modulate wound healing have shown positive results on the 
      experimental level. Patient selection based on the concentration of epidermal 
      growth factor in tears may be another way to increase PRK s precision. The PRK 
      technique has taught much about wound healing. For the technique to be 
      competitive, increased precision, particularly in eyes with high myopia, is 
      needed. Two other factors are imperative: controlling postoperative pain and 
      decreasing visual rehabilitation time.
FAU - Fagerholm, P
AU  - Fagerholm P
AD  - St. Eriks Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Cataract Refract Surg
JT  - Journal of cataract and refractive surgery
JID - 8604171
RN  - 0 (Glucocorticoids)
RN  - 0 (Growth Substances)
RN  - 0 (Ophthalmic Solutions)
SB  - IM
CIN - J Cataract Refract Surg. 2000 Mar;26(3):303-4. PMID: 10713222
MH  - Animals
MH  - Cornea/drug effects/metabolism/*pathology/surgery
MH  - Glucocorticoids/administration & dosage
MH  - Growth Substances/metabolism
MH  - Humans
MH  - Lasers, Excimer
MH  - Ophthalmic Solutions
MH  - *Photorefractive Keratectomy
MH  - Postoperative Complications/pathology/prevention & control
MH  - Refractive Surgical Procedures
MH  - *Wound Healing/drug effects/physiology
RF  - 164
EDAT- 2000/03/14 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/03/14 09:00
PHST- 2000/03/14 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/14 09:00 [entrez]
AID - S0886-3350(99)00436-8 [pii]
AID - 10.1016/s0886-3350(99)00436-8 [doi]
PST - ppublish
SO  - J Cataract Refract Surg. 2000 Mar;26(3):432-47. doi: 
      10.1016/s0886-3350(99)00436-8.