PMID- 10716249
OWN - NLM
STAT- MEDLINE
DCOM- 20000508
LR  - 20081121
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 47
IP  - 3
DP  - 2000 Mar
TI  - Increased lymphoproliferative response to human herpesvirus type 6A variant in 
      multiple sclerosis patients.
PG  - 306-13
AB  - Several reports have suggested an association of human herpesvirus 6 (HHV-6) and 
      multiple sclerosis (MS) based on immunohistochemical demonstration of HHV-6 
      antigens in inflammatory lesions, detection of increased HHV-6 specific serum 
      antibody titers, and amplification of HHV-6 DNA from sera and cerebrospinal fluid 
      of MS patients but not in controls. Characterization of the cellular immune 
      response of MS patients to HHV-6 may further clarify the role of HHV-6 in MS and 
      provide insight into the pathogenesis of this immune-mediated disease. We have 
      compared lymphoproliferative responses to HHV-6A (U1102)-, HHV-6B (Z29)-, and 
      HHV-7 (H7SB)-infected cell lysates in healthy controls and patients with MS. Most 
      healthy controls (71%) proliferated to HHV-6B lysate, and fewer (33%) responded 
      to the HHV-6A lysate. In contrast, 67% of MS patients had a lymphoproliferative 
      response to HHV-6A, which is a significant increase in comparison with healthy 
      controls. A similar frequency of lymphoproliferative response (78%) to HHV-6B was 
      demonstrated in MS patients. Lymphoproliferation to HHV-7 lysate was demonstrated 
      in 23% of healthy controls and 28% of MS patients. These results indicate that 
      the lymphoproliferative response to the HHV-6A variant, which was recently 
      reported to have greater neurotropism, is increased in MS patients.
FAU - Soldan, S S
AU  - Soldan SS
AD  - Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, 
      National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Leist, T P
AU  - Leist TP
FAU - Juhng, K N
AU  - Juhng KN
FAU - McFarland, H F
AU  - McFarland HF
FAU - Jacobson, S
AU  - Jacobson S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - *Lymphocyte Activation
MH  - Multiple Sclerosis/*immunology/metabolism
EDAT- 2000/03/15 09:00
MHDA- 2000/05/16 09:00
CRDT- 2000/03/15 09:00
PHST- 2000/03/15 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 2000/03/15 09:00 [entrez]
PST - ppublish
SO  - Ann Neurol. 2000 Mar;47(3):306-13.