PMID- 10716929
OWN - NLM
STAT- MEDLINE
DCOM- 20000427
LR  - 20221115
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 19
IP  - 6
DP  - 2000 Mar 15
TI  - BDNF regulates eating behavior and locomotor activity in mice.
PG  - 1290-300
AB  - Brain-derived neurotrophic factor (BDNF) was studied initially for its role in 
      sensory neuron development. Ablation of this gene in mice leads to death shortly 
      after birth, and abnormalities have been found in both the peripheral and central 
      nervous systems. BDNF and its tyrosine kinase receptor, TrkB, are expressed in 
      hypothalamic nuclei associated with satiety and locomotor activity. In 
      heterozygous mice, BDNF gene expression is reduced and we find that all 
      heterozygous mice exhibit abnormalities in eating behavior or locomotor activity. 
      We also observe this phenotype in independently derived inbred and hybrid BDNF 
      mutant strains. Infusion with BDNF or NT4/5 can transiently reverse the eating 
      behavior and obesity. Thus, we identify a novel non-neurotrophic function for 
      neurotrophins and indicate a role in behavior that is remarkably sensitive to 
      alterations in BDNF activity.
FAU - Kernie, S G
AU  - Kernie SG
AD  - Center for Developmental Biology, U.T. Southwestern Medical Center, 6000 Harry 
      Hines Blvd, Dallas, TX 75235-9133, USA.
FAU - Liebl, D J
AU  - Liebl DJ
FAU - Parada, L F
AU  - Parada LF
LA  - eng
GR  - P41 RR002584/RR/NCRR NIH HHS/United States
GR  - R37 NS033199/NS/NINDS NIH HHS/United States
GR  - P41-RR02584/RR/NCRR NIH HHS/United States
GR  - R01 NS33199-05/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carrier Proteins)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Leptin)
RN  - 0 (cocaine- and amphetamine-regulated transcript protein)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adipocytes/cytology
MH  - Animals
MH  - Appetite/genetics/physiology
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/blood/deficiency/genetics/*physiology
MH  - Carrier Proteins/analysis
MH  - Feeding Behavior/*physiology
MH  - Female
MH  - Heterozygote
MH  - Humans
MH  - Hypothalamus/cytology/metabolism
MH  - Insulin/blood
MH  - Leptin/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Motor Activity/genetics/*physiology
MH  - Nerve Tissue Proteins/analysis/genetics
MH  - Neuropeptide Y/analysis
MH  - Obesity/genetics/pathology
MH  - RNA, Messenger/analysis/genetics
MH  - Receptor, trkB/genetics
MH  - *Receptors, Cell Surface
MH  - Receptors, Leptin
PMC - PMC305670
EDAT- 2000/03/16 09:00
MHDA- 2000/04/29 09:00
PMCR- 2001/03/15
CRDT- 2000/03/16 09:00
PHST- 2000/03/16 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/16 09:00 [entrez]
PHST- 2001/03/15 00:00 [pmc-release]
AID - 191290 [pii]
AID - 10.1093/emboj/19.6.1290 [doi]
PST - ppublish
SO  - EMBO J. 2000 Mar 15;19(6):1290-300. doi: 10.1093/emboj/19.6.1290.