PMID- 10718272
OWN - NLM
STAT- MEDLINE
DCOM- 20000419
LR  - 20190910
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 114
IP  - 1
DP  - 2000 Feb
TI  - Dopamine D2 receptors in the nucleus accumbens are important for social 
      attachment in female prairie voles (Microtus ochrogaster).
PG  - 173-83
AB  - The prairie vole (Microtus ochrogaster), a monogamous rodent that forms 
      long-lasting pair bonds, has proven useful for the neurobiological study of 
      social attachment. In the laboratory, pair bonds can be assessed by testing for a 
      partner preference, a choice test in which pair-bonded voles regularly prefer 
      their partner to a conspecific stranger. Studies reported here investigate the 
      role of dopamine D2-like receptors (i.e., D2, D3, and D4 receptors) in the 
      nucleus accumbens (NAcc) for the formation of a partner preference in female 
      voles. Mating facilitated partner preference formation and associated with an 
      approximately 50% increase in extracellular dopamine in the NAcc. Microinjection 
      of the D2 antagonist eticlopride into the NAcc (but not the prelimbic cortex) 
      blocked the formation of a partner preference in mating voles, whereas the D2 
      agonist quinpirole facilitated formation of a partner preference in the absence 
      of mating. Taken together, these results suggest that D2-like receptors in the 
      NAcc are important for the mediation of social attachments in female voles.
FAU - Gingrich, B
AU  - Gingrich B
AD  - Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, 
      Georgia 30322, USA.
FAU - Liu, Y
AU  - Liu Y
FAU - Cascio, C
AU  - Cascio C
FAU - Wang, Z
AU  - Wang Z
FAU - Insel, T R
AU  - Insel TR
LA  - eng
GR  - R01-MH56539/MH/NIMH NIH HHS/United States
GR  - R29-MH54554/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Receptors, Dopamine D2)
SB  - IM
MH  - Animals
MH  - Arvicolinae/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Nucleus Accumbens/*physiology
MH  - *Pair Bond
MH  - Receptors, Dopamine D2/*physiology
MH  - Sexual Behavior, Animal/physiology
MH  - *Social Behavior
EDAT- 2000/03/16 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/03/16 09:00
PHST- 2000/03/16 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/03/16 09:00 [entrez]
AID - 10.1037//0735-7044.114.1.173 [doi]
PST - ppublish
SO  - Behav Neurosci. 2000 Feb;114(1):173-83. doi: 10.1037//0735-7044.114.1.173.