PMID- 10719836
OWN - NLM
STAT- MEDLINE
DCOM- 20000330
LR  - 20221011
IS  - 0037-9727 (Print)
IS  - 0037-9727 (Linking)
VI  - 223
IP  - 3
DP  - 2000 Mar
TI  - Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis.
PG  - 241-57
AB  - Tumor necrosis factor-alpha (TNF-alpha) and TNF receptors (TNFR) are members of 
      the growing TNF ligand and receptor families that are involved in immune 
      regulation. The present report will focus on the role of the prototypic ligand 
      TNF and its two receptors, TNFR1 and TNFR2, in viral pathogenesis. Although TNF 
      was reported years ago to modulate viral infections, recent findings on the 
      molecular pathways involved in TNFR signaling have allowed a better understanding 
      of the molecular interactions between cellular and viral factors within the 
      infected cell. The interactions of viral proteins with intracellular components 
      downstream of the TNFR have highlighted at the molecular level how viruses can 
      manipulate the cellular machinery to escape the immune response and to favor the 
      spread of the infection. We will review here the role of TNF and TNFR in immune 
      response and the role of TNF and TNFR signaling in viral pathogenesis.
FAU - Herbein, G
AU  - Herbein G
AD  - Department of Internal Medicine, University of Texas Medical Branch, Galveston 
      77555-0835, USA. geherbei@utmb.edu
FAU - O'Brien, W A
AU  - O'Brien WA
LA  - eng
GR  - NS 38414/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Proc Soc Exp Biol Med
JT  - Proceedings of the Society for Experimental Biology and Medicine. Society for 
      Experimental Biology and Medicine (New York, N.Y.)
JID - 7505892
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - DNA Viruses/pathogenicity
MH  - Humans
MH  - RNA Viruses/pathogenicity
MH  - Receptors, Tumor Necrosis Factor/*immunology
MH  - Tumor Necrosis Factor-alpha/*immunology
MH  - Virus Diseases/*etiology/immunology/virology
RF  - 196
EDAT- 2000/03/17 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/17 09:00
PHST- 2000/03/17 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/17 09:00 [entrez]
AID - 10.1177/153537020022300305 [doi]
PST - ppublish
SO  - Proc Soc Exp Biol Med. 2000 Mar;223(3):241-57. doi: 10.1177/153537020022300305.