PMID- 10720058
OWN - NLM
STAT- MEDLINE
DCOM- 20000330
LR  - 20051117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 85
IP  - 3
DP  - 2000 Mar
TI  - Binding of human thyrotropin receptor peptides to a Graves' disease-predisposing 
      human leukocyte antigen class II molecule.
PG  - 1176-9
AB  - There are many reports that Graves' disease (GD) is associated with certain human 
      leukocyte antigen (HLA) molecules, in particular DR3. Here we examined the 
      characteristics of binding of human TSH receptor (TSHR) peptides to this 
      disease-associated HLA class II molecule. DR3 molecules bind TSHR immunodominant 
      peptide epitopes with intermediate affinity. On the contrary, DR3 binds 
      nonimmunogenic peptides either with poor affinity or not at all, with one 
      exceptional peptide that has extremely high affinity. These results suggest that 
      susceptibility to GD associated with inheritance of a specific HLA class II gene 
      is due to the influence of the HLA molecule-TSHR peptide complex on the T cell 
      repertoire.
FAU - Sawai, Y
AU  - Sawai Y
AD  - Department of Medicine, University of Chicago, Illinois 60637, USA.
FAU - DeGroot, L J
AU  - DeGroot LJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Epitopes)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Thyrotropin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antibodies, Monoclonal/analysis
MH  - Cell Line
MH  - Epitopes/immunology
MH  - Genes, MHC Class II/*genetics
MH  - Graves Disease/genetics/*metabolism
MH  - HLA-DR3 Antigen/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Peptides/*metabolism
MH  - Protein Binding
MH  - Receptors, Thyrotropin/*metabolism
EDAT- 2000/03/17 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/17 09:00
PHST- 2000/03/17 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/17 09:00 [entrez]
AID - 10.1210/jcem.85.3.6376 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2000 Mar;85(3):1176-9. doi: 10.1210/jcem.85.3.6376.