PMID- 10720137
OWN - NLM
STAT- MEDLINE
DCOM- 20000407
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 14
IP  - 3
DP  - 2000 Mar
TI  - Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL).
PG  - 427-30
AB  - Deletions of the long arm of chromosomes 11 and 13 are the most frequent 
      structural chromosome aberrations in various types of lymphoproliferative 
      disorders. However, these regions have not been studied so far in B cell 
      prolymphocytic leukemia (B-PLL). We have investigated the incidence of 13q 
      deletions in 18 B-PLL cases by fluorescence in situ hybridization (FISH), using 
      molecular probes for the RB1 and D13S25 loci. Chromosome 11q deletions were 
      evaluated by FISH using the yeast artificial chromosome (YAC) clone 755b11 from 
      the chromosome 11q22.3-q23.1 region, which has been previously shown to be 
      deleted in 20% of cases of chronic lymphocytic leukemia. Chromosome 11q23 
      deletions were found in 7/18 (39%) cases of B-PLL. Monoallelic loss of RB1, 
      D13S25 and BRCA2 was present in 10/18 (55%), 6/18 (33%) and 3/18 (16%) of the 
      cases, respectively. All the cases with D13S25 and BRCA2 deletion showed RB1 
      loss. Deletions of 13q14 and 11q23 are frequent chromosome aberrations in B-PLL 
      and, in contrast to CLL, there is a preferential loss of RB1 with respect to the 
      D13S25 locus suggesting that allelic loss of the RB1 gene may play a role in the 
      pathogenesis of B-PLL.
FAU - Lens, D
AU  - Lens D
AD  - Academic Department of Haematology and Cytogenetics, Royal Marsden 
      Hospital/Institute of Cancer Research, London/Sutton, UK.
FAU - Matutes, E
AU  - Matutes E
FAU - Catovsky, D
AU  - Catovsky D
FAU - Coignet, L J
AU  - Coignet LJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - *Chromosome Deletion
MH  - Chromosomes, Artificial, Yeast
MH  - Chromosomes, Human, Pair 11/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 13/*genetics/ultrastructure
MH  - Female
MH  - Genes, Retinoblastoma
MH  - Genes, p53
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
EDAT- 2000/03/17 00:00
MHDA- 2000/03/17 00:01
CRDT- 2000/03/17 00:00
PHST- 2000/03/17 00:00 [pubmed]
PHST- 2000/03/17 00:01 [medline]
PHST- 2000/03/17 00:00 [entrez]
AID - 10.1038/sj.leu.2401644 [doi]
PST - ppublish
SO  - Leukemia. 2000 Mar;14(3):427-30. doi: 10.1038/sj.leu.2401644.