PMID- 10720327
OWN - NLM
STAT- MEDLINE
DCOM- 20000404
LR  - 20220410
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 287
IP  - 5460
DP  - 2000 Mar 17
TI  - Prostaglandin D2 as a mediator of allergic asthma.
PG  - 2013-7
AB  - Allergic asthma is caused by the aberrant expansion in the lung of T helper cells 
      that produce type 2 (TH2) cytokines and is characterized by infiltration of 
      eosinophils and bronchial hyperreactivity. This disease is often triggered by 
      mast cells activated by immunoglobulin E (IgE)-mediated allergic challenge. 
      Activated mast cells release various chemical mediators, including prostaglandin 
      D2 (PGD2), whose role in allergic asthma has now been investigated by the 
      generation of mice deficient in the PGD receptor (DP). Sensitization and aerosol 
      challenge of the homozygous mutant (DP-/-) mice with ovalbumin (OVA) induced 
      increases in the serum concentration of IgE similar to those in wild-type mice 
      subjected to this model of asthma. However, the concentrations of TH2 cytokines 
      and the extent of lymphocyte accumulation in the lung of OVA-challenged DP-/- 
      mice were greatly reduced compared with those in wild-type animals. Moreover, 
      DP-/- mice showed only marginal infiltration of eosinophils and failed to develop 
      airway hyperreactivity. Thus, PGD2 functions as a mast cell-derived mediator to 
      trigger asthmatic responses.
FAU - Matsuoka, T
AU  - Matsuoka T
AD  - Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606-8501, 
      Japan.
FAU - Hirata, M
AU  - Hirata M
FAU - Tanaka, H
AU  - Tanaka H
FAU - Takahashi, Y
AU  - Takahashi Y
FAU - Murata, T
AU  - Murata T
FAU - Kabashima, K
AU  - Kabashima K
FAU - Sugimoto, Y
AU  - Sugimoto Y
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Ushikubi, F
AU  - Ushikubi F
FAU - Aze, Y
AU  - Aze Y
FAU - Eguchi, N
AU  - Eguchi N
FAU - Urade, Y
AU  - Urade Y
FAU - Yoshida, N
AU  - Yoshida N
FAU - Kimura, K
AU  - Kimura K
FAU - Mizoguchi, A
AU  - Mizoguchi A
FAU - Honda, Y
AU  - Honda Y
FAU - Nagai, H
AU  - Nagai H
FAU - Narumiya, S
AU  - Narumiya S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Allergens)
RN  - 0 (Interleukins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Prostaglandin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
RN  - RXY07S6CZ2 (Prostaglandin D2)
RN  - XZF106QU24 (prostaglandin D2 receptor)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Asthma/immunology/metabolism/pathology/*physiopathology
MH  - Bronchial Hyperreactivity
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Crosses, Genetic
MH  - Female
MH  - Gene Targeting
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/metabolism
MH  - Interleukins/metabolism
MH  - Lung/immunology/metabolism/pathology
MH  - Lymphocytes/immunology
MH  - Male
MH  - Mast Cells/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mucus/metabolism
MH  - Ovalbumin/immunology
MH  - Prostaglandin D2/metabolism/*physiology
MH  - *Receptors, Immunologic
MH  - Receptors, Prostaglandin/genetics/metabolism/*physiology
MH  - Respiratory Mucosa/metabolism
EDAT- 2000/03/17 00:00
MHDA- 2000/03/17 00:01
CRDT- 2000/03/17 00:00
PHST- 2000/03/17 00:00 [pubmed]
PHST- 2000/03/17 00:01 [medline]
PHST- 2000/03/17 00:00 [entrez]
AID - 8366 [pii]
AID - 10.1126/science.287.5460.2013 [doi]
PST - ppublish
SO  - Science. 2000 Mar 17;287(5460):2013-7. doi: 10.1126/science.287.5460.2013.