PMID- 10720722
OWN - NLM
STAT- MEDLINE
DCOM- 20000504
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 112-113
DP  - 2000 Mar 15
TI  - Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs 
      ('Ecstasy').
PG  - 133-42
AB  - The phase I and II metabolites of the designer drugs methylenedioxyamphetamine 
      (MDA), R,S-methylenedioxymethamphetamine (MDMA), 
      R,S-methylenedioxyethylamphetamine (MDE), R, S-benzodioxazolylbutanamine (BDB) 
      and R, S-N-methyl-benzodioxazolylbutanamine (MBDB) were identified by gas 
      chromatography-mass spectrometry (GC-MS) or liquid chromotography-mass 
      spectrometry (LC-MS) in urine and liver microsomes of humans and rats. Two 
      overlapping pathways could be postulated: (1) demethylenation followed by 
      catechol-O-methyl-transferase (COMT) catalyzed methylation and/or 
      glucuronidation/sulfatation; (2) N-dealkylation, deamination and only for MDA, 
      MDMA, MDE oxidation to the corresponding benzoic acid derivatives conjugated with 
      glycine. Demethylenation was mainly catalyzed by CYP2D1/6 or CYP3A2/4, but also 
      by CYP independent mechanisms. In humans, MDMA and MBDB could also be 
      demethylenated by CYP1A2. N-demethylation was mainly catalyzed by CYP1A2, 
      N-deethylation by CYP3A2/4. Based on these studies, GC-MS procedures were 
      developed for the toxicological analysis in urine and plasma. Finally, 
      toxicokinetic parameters are reviewed.
FAU - Maurer, H H
AU  - Maurer HH
AD  - Department of Toxicology, Institute of Pharmacology, University of Saarland, 
      D-66421, Homburg, Germany. hans.maurer@med.rz.uni.sb.de
FAU - Bickeboeller-Friedrich, J
AU  - Bickeboeller-Friedrich J
FAU - Kraemer, T
AU  - Kraemer T
FAU - Peters, F T
AU  - Peters FT
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Amphetamines)
RN  - 0 (Designer Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - *Amphetamines/metabolism/pharmacokinetics/toxicity
MH  - Animals
MH  - Area Under Curve
MH  - Chromatography, Liquid
MH  - *Designer Drugs/metabolism/pharmacokinetics/toxicity
MH  - Gas Chromatography-Mass Spectrometry
MH  - Half-Life
MH  - Humans
MH  - Liver/*metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/metabolism/pharmacokinetics/toxicity
MH  - Rats
MH  - Rats, Wistar
MH  - Species Specificity
EDAT- 2000/03/18 09:00
MHDA- 2000/05/08 09:00
CRDT- 2000/03/18 09:00
PHST- 2000/03/18 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 2000/03/18 09:00 [entrez]
AID - S0378427499002076 [pii]
AID - 10.1016/s0378-4274(99)00207-6 [doi]
PST - ppublish
SO  - Toxicol Lett. 2000 Mar 15;112-113:133-42. doi: 10.1016/s0378-4274(99)00207-6.