PMID- 10725920
OWN - NLM
STAT- MEDLINE
DCOM- 20000421
LR  - 20220309
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 3
IP  - 4
DP  - 2000 Apr
TI  - Synapsins as mediators of BDNF-enhanced neurotransmitter release.
PG  - 323-9
AB  - We examined enhancement of synaptic transmission by neurotrophins at the 
      presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic 
      factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin 
      I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used 
      to inhibit MAP kinase activity, markedly decreased synapsin I phosphorylation and 
      concomitantly reduced neurotransmitter release. The stimulation of glutamate 
      release by BDNF was strongly attenuated in mice lacking synapsin I and/or 
      synapsin II. These results indicate a causal link of synapsin phosphorylation via 
      BDNF, TrkB receptors and MAP kinase with downstream facilitation of 
      neurotransmitter release.
FAU - Jovanovic, J N
AU  - Jovanovic JN
AD  - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 
      New York, New York 10021, USA.
FAU - Czernik, A J
AU  - Czernik AJ
FAU - Fienberg, A A
AU  - Fienberg AA
FAU - Greengard, P
AU  - Greengard P
FAU - Sihra, T S
AU  - Sihra TS
LA  - eng
GR  - AG15072/AG/NIA NIH HHS/United States
GR  - MH39327/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Flavonoids)
RN  - 0 (Synapsins)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - SJE1IO5E3I (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Enzyme Inhibitors/pharmacology
MH  - Flavonoids/pharmacology
MH  - Gene Expression Regulation, Enzymologic
MH  - Glutamic Acid/*metabolism
MH  - MAP Kinase Signaling System/drug effects/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Neurons/enzymology
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stimulation, Chemical
MH  - Synapsins/genetics/*metabolism
MH  - Synaptic Transmission/*drug effects/*physiology
MH  - Synaptosomes/enzymology
EDAT- 2000/03/22 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/03/22 09:00
PHST- 2000/03/22 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/22 09:00 [entrez]
AID - 10.1038/73888 [doi]
PST - ppublish
SO  - Nat Neurosci. 2000 Apr;3(4):323-9. doi: 10.1038/73888.