PMID- 10727752
OWN - NLM
STAT- MEDLINE
DCOM- 20000602
LR  - 20190910
IS  - 0192-0561 (Print)
IS  - 0192-0561 (Linking)
VI  - 22
IP  - 6
DP  - 2000 Jun
TI  - Inhibitory effect of anaphylactic shock by caffeine in rats.
PG  - 411-8
AB  - Caffeine is known to reduce evoked histamine secretion, but the effects of 
      caffeine on anaphylactic shock have not been clarified. We have investigated the 
      effects of caffeine on anaphylactic shock in rats. Systemic anaphylactic shock by 
      compound 48/80 injection was monitored for 1 h. An IgE-dependent local 
      anaphylactic shock was generated by sensitizing the skin with anti-dinitrophenyl 
      (DNP) IgE followed 48 h later with an injection of antigen. Caffeine inhibited 
      compound 48/80-induced anaphylatic shock to 40% with a dose of 1 mg/kg. Caffeine 
      (0.1 mg/kg) inhibited to 56.4+/-0.4% passive cutaneous anaphylactic shock 
      activated by anti-DNP IgE. Caffeine (5-20 mM) significantly inhibited histamine 
      release from rat peritoneal mast cells (RPMCs) activated by compound 48/80 or 
      anti-DNP IgE. Especially, caffeine (20 mM) inhibited by 96.7+/-0.5% histamine 
      release activated by compound 48/80. Moreover, caffeine (1-20 mM) had a 
      significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha 
      production from RPMCs. The level of cAMP in RPMCs, when caffeine (20 mM) was 
      added, increased significantly after 5-60 min compared with that of a normal 
      control. These results indicate that caffeine inhibits immediate-type allergic 
      reactions by inhibition of mast cell degranulation in vivo and in vitro.
FAU - Shin, H Y
AU  - Shin HY
AD  - College of Pharmacy, Center of Oriental Medicinal Science, Wonkwang University, 
      Iksan, Chonbuk 570-749, South Korea.
FAU - Lee, C S
AU  - Lee CS
FAU - Chae, H J
AU  - Chae HJ
FAU - Kim, H R
AU  - Kim HR
FAU - Baek, S H
AU  - Baek SH
FAU - An, N H
AU  - An NH
FAU - Kim, M H
AU  - Kim MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopharmacol
JT  - International journal of immunopharmacology
JID - 7904799
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3G6A5W338E (Caffeine)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/*drug therapy
MH  - Animals
MH  - Caffeine/*therapeutic use
MH  - Central Nervous System Stimulants/*therapeutic use
MH  - Cyclic AMP/biosynthesis
MH  - Dinitrobenzenes/immunology
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/immunology
MH  - Mast Cells/drug effects/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Peritoneal Cavity/cytology
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 2000/03/23 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/03/23 09:00
PHST- 2000/03/23 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/03/23 09:00 [entrez]
AID - S0192056100000060 [pii]
AID - 10.1016/s0192-0561(00)00006-0 [doi]
PST - ppublish
SO  - Int J Immunopharmacol. 2000 Jun;22(6):411-8. doi: 10.1016/s0192-0561(00)00006-0.