PMID- 10730900
OWN - NLM
STAT- MEDLINE
DCOM- 20000328
LR  - 20220409
IS  - 1351-0088 (Print)
IS  - 1351-0088 (Linking)
VI  - 6
IP  - 4
DP  - 1999 Dec
TI  - Multiple endocrine neoplasia type 1.
PG  - 449-73
AB  - Combined clinical and laboratory investigations of multiple endocrine neoplasia 
      type 1 (MEN1) have resulted in an increased understanding of this disorder which 
      may be inherited as an autosomal dominant condition. Defining the features of 
      each disease manifestation in MEN1 has improved patient management and treatment, 
      and has also facilitated a screening protocol to be instituted. The application 
      of the techniques of molecular biology has enabled the identification of the gene 
      causing MEN1 and the detection of mutations in patients. The function of the 
      protein encoded by the MEN1 gene has been shown to be in the regulation of 
      JunD-mediated transcription but much still remains to be elucidated. However, 
      these recent advances provide for the identification of mutant MEN1 gene carriers 
      who are at a high risk of developing this disorder and thus require regular and 
      biochemical screening to detect the development of endocrine tumours.
FAU - Pannett, A A
AU  - Pannett AA
AD  - Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
FAU - Thakker, R V
AU  - Thakker RV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Endocr Relat Cancer
JT  - Endocrine-related cancer
JID - 9436481
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - *Genes, Tumor Suppressor
MH  - Genetic Testing
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - *Mutation
MH  - Neoplasm Proteins/*genetics
MH  - Pancreatic Neoplasms/genetics
MH  - Parathyroid Neoplasms/genetics
MH  - Pituitary Neoplasms/genetics
MH  - *Proto-Oncogene Proteins
RF  - 75
EDAT- 2000/03/24 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/03/24 09:00
PHST- 2000/03/24 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/03/24 09:00 [entrez]
AID - 10.1677/erc.0.0060449 [doi]
PST - ppublish
SO  - Endocr Relat Cancer. 1999 Dec;6(4):449-73. doi: 10.1677/erc.0.0060449.