PMID- 10733618
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1878-5506 (Electronic)
IS  - 1389-9457 (Linking)
VI  - 1
IP  - 1
DP  - 2000 Feb 1
TI  - Clinical and polysomnographic features in DQB1*0602 positive and negative 
      narcolepsy patients: results from the modafinil clinical trial.
PG  - 33-39
AB  - Background: Narcolepsy, a neurological disorder characterized by excessive 
      daytime sleepiness and abnormal REM sleep, is known to be tightly associated with 
      the human leukocyte antigen (HLA) DQB1*0602.Methods: In this study, baseline data 
      collected for a large clinical trial involving 504 narcolepsy patients were used 
      to compare clinical and polysomnographic features of narcolepsy patients with and 
      without HLA-DQB1*0602. Comparisons were adjusted for possible confounding factors 
      and linear regression modeling was used to extract the best predictors for 
      DQB1*0602 positivity.Results: As previously reported, cataplexy was the best 
      clinical predictor for DQB1*0602 positivity. At the polysomnographic level, 
      subjects with DQB1*0602 were found to have a significantly more disrupted 
      nocturnal sleep, a much shorter nocturnal rapid eye movement (REM) sleep latency 
      and more multiple sleep latency test abnormalities (increased number of sleep 
      onset REM periods and decreased mean sleep latency). We also found that subjects 
      with DQB1*0602 had a much higher incidence of periodic limb movements during 
      sleep, confirming the notion that this symptom is genuinely associated with the 
      narcolepsy phenotype.Conclusions: These results support the notion that 
      HLA-DQB1*0602-positive narcolepsy patients are more etiologically homogenous than 
      HLA-DQB1*0602-negative narcoleptic patients.
FAU - Hong, SC
AU  - Hong SC
AD  - Department of Neuropsychiatry, St. Vincent's Hospital, College of Medicine, 
      Catholic University of Korea, Seoul, South Korea
FAU - Hayduk, R
AU  - Hayduk R
FAU - Lim, J
AU  - Lim J
FAU - Mignot, E
AU  - Mignot E
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Sleep Med
JT  - Sleep medicine
JID - 100898759
EDAT- 2000/03/25 00:00
MHDA- 2000/03/25 00:01
CRDT- 2000/03/25 00:00
PHST- 2000/03/25 00:00 [pubmed]
PHST- 2000/03/25 00:01 [medline]
PHST- 2000/03/25 00:00 [entrez]
AID - S1389-9457(99)00007-6 [pii]
AID - 10.1016/s1389-9457(99)00007-6 [doi]
PST - ppublish
SO  - Sleep Med. 2000 Feb 1;1(1):33-39. doi: 10.1016/s1389-9457(99)00007-6.