PMID- 10741902
OWN - NLM
STAT- MEDLINE
DCOM- 20000511
LR  - 20190921
IS  - 0162-3109 (Print)
IS  - 0162-3109 (Linking)
VI  - 46
IP  - 3
DP  - 2000 Mar
TI  - An assessment of the acute effects of the serotonin releasers 
      methylenedioxymethamphetamine, methylenedioxyamphetamine and fenfluramine on 
      immunity in rats.
PG  - 223-35
AB  - The purpose of the present study was to examine the effect of the serotonin 
      releasing amphetamine derivatives methylenedioxymethamphetamine (MDMA), 
      methylenedioxyamphetamine (MDA) and fenfluramine (FEN) on immunity in rats. 
      Similar to MDA and MDMA, FEN reduced the number of circulating lymphocytes, 
      provoked a suppression of Con A-stimulated lymphocyte proliferation and total 
      IFN-gamma and IL-10 production in diluted whole blood cultures. Thus the 
      non-psychostimulant amphetamine derivative FEN, shares the ability of the 
      psychostimulant methylenedioxy-substituted amphetamine derivatives to alter these 
      indices of immune function in the rat. However, when Con A-stimulated cytokine 
      production was normalised for the number of lymphocytes in culture in order to 
      examine cytokine production at a cellular level, the effect of the amphetamine 
      derivatives begins to diverge. FEN shares with MDMA and MDA the ability to 
      suppress production of the Th2 type cytokine IL-10. However the effect of these 
      drugs on Th1 type cytokine secretion was much more complex. While the 
      methylendioxy-substituted amphetamines increases the secretion of the Th1 type 
      cytokine IL-2 without altering the related Th1 type cytokine IFN-gamma, FEN did 
      not alter IL-2 secretion, but suppressed IFN-gamma secretion. In addition to 
      these effects on T-cell responses, all three drugs inhibited LPS-induced 
      TNF-alpha secretion from diluted whole blood cultures suggesting that macrophage 
      activity is impaired following treatment. In all, these data extend our previous 
      findings concerning the effects of MDMA on the immune system and demonstrate that 
      the related serotonin releasers MDA and FEN also provoke immunological changes in 
      rats.
FAU - Connor, T J
AU  - Connor TJ
AD  - Department of Pharmacology, National University of Ireland, Galway. 
      thomas.connor@nuigalway.ie
FAU - Kelly, J P
AU  - Kelly JP
FAU - Leonard, B E
AU  - Leonard BE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunopharmacology
JT  - Immunopharmacology
JID - 7902474
RN  - 0 (Cytokines)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Serotonin Agents)
RN  - 11028-71-0 (Concanavalin A)
RN  - 2DS058H2CF (Fenfluramine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*pharmacology
MH  - Animals
MH  - Concanavalin A/pharmacology
MH  - Cytokines/biosynthesis
MH  - Female
MH  - Fenfluramine/*pharmacology
MH  - Immunity/*drug effects
MH  - Leukocyte Count
MH  - Lipopolysaccharides/pharmacology
MH  - Lymphocyte Activation/drug effects
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Agents/*pharmacology
EDAT- 2000/03/31 09:00
MHDA- 2000/05/16 09:00
CRDT- 2000/03/31 09:00
PHST- 2000/03/31 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 2000/03/31 09:00 [entrez]
AID - S0162310999001800 [pii]
AID - 10.1016/s0162-3109(99)00180-0 [doi]
PST - ppublish
SO  - Immunopharmacology. 2000 Mar;46(3):223-35. doi: 10.1016/s0162-3109(99)00180-0.