PMID- 10746121 OWN - NLM STAT- MEDLINE DCOM- 20000420 LR - 20190728 IS - 0042-6989 (Print) IS - 0042-6989 (Linking) VI - 39 IP - 21 DP - 1999 Oct TI - Spatio-temporal tuning of VEPs: effect of mode of stimulation. PG - 3491-7 AB - The spatial tuning function of the 8 Hz reversal Visual Evoked Potential (VEP) is frequently bimodal. This amplitude 'notch' largely disappears with 16 Hz pattern onset-offset (on-off) stimulation. To investigate the effect of temporal frequency on this phenomenon, we tested seven subjects using a range of rates centred on 8 Hz (reversal) and 16 Hz (on-off). With reversal, a deep notch was present at all temporal frequencies. A much shallower notch was evident with on-off. The on-off and reversal functions differed only in their low spatial frequency branches (below 4.5 c deg-1) where, as temporal frequency decreased, the reversal response was reduced by 50%, whilst the on-off responses doubled in amplitude. Thus, although they behave differently with on-off and reversal, multiple spatial frequency mechanisms are evident with both forms of stimulation. FAU - Parry, N R AU - Parry NR AD - Vision Science Centre, Manchester Royal Eye Hospital, UK. neil.parry@man.ac.uk FAU - Murray, I J AU - Murray IJ FAU - Hadjizenonos, C AU - Hadjizenonos C LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Vision Res JT - Vision research JID - 0417402 SB - IM MH - Contrast Sensitivity/physiology MH - Evoked Potentials, Visual/*physiology MH - Humans MH - Photic Stimulation MH - Time Factors EDAT- 2000/04/04 09:00 MHDA- 2000/04/25 09:00 CRDT- 2000/04/04 09:00 PHST- 2000/04/04 09:00 [pubmed] PHST- 2000/04/25 09:00 [medline] PHST- 2000/04/04 09:00 [entrez] AID - S0042-6989(99)00098-X [pii] AID - 10.1016/s0042-6989(99)00098-x [doi] PST - ppublish SO - Vision Res. 1999 Oct;39(21):3491-7. doi: 10.1016/s0042-6989(99)00098-x.