PMID- 10746240
OWN - NLM
STAT- MEDLINE
DCOM- 20000503
LR  - 20191210
IS  - 0465-5893 (Print)
IS  - 0465-5893 (Linking)
VI  - 50
IP  - 6
DP  - 1999
TI  - [Bronchial hyperreactivity as a factors of chronic obstructive pulmonary disease 
      development in the population of the Bogdanka coal miners].
PG  - 537-47
AB  - The aim of the study was to assess the role of bronchial hyperreactivity in the 
      development of chronic airflow obstruction in the population of the Bogdanka 
      (Lublin Basin) coal miners. The population examined consisted of 1456 coal miners 
      working underground in the Bogdanka colliery. The methods of the study included 
      plethysmographic measurements of total airway resistance (Raw), spirometric 
      measurements of forced expiratory volume in one second (FEV1), and determination 
      of forced expiratory flowa at 75, 50 and 25 per cent of vital capacity (FEF75, 
      FEF50 and FEF25%VC). The measurements were repeated twice--before and after 
      administration of 0.2% solution of methacholine (1 min inhalation). Pulmonary 
      function tests were also performed 8 years after initial measurements. The 
      increase in the Raw value above 0.6 kPa/l/s was observed in 5.5% of the 
      population examined. In this group of subjects the skin prick tests with common 
      allergens, measurements of total immunoglobulin E (IgE) levels and determination 
      of blood eosinophils count were performed. Only 12% of all hyperreactives (Raw 
      increase > 0.6 kPa/l/s) showed features of atopy--positive skin prick tests, 
      raised IgE levels, and increase in blood eosinophils count. Using a survival 
      analysis as a statistical tool we evaluated for how long the pulmonary function 
      tests remained within normal ranges in two groups: hyperreactives and controls. 
      All hyperreactives (atopic and non-atopic) showed significantly higher risk of 
      lung function decrease below the normal values as compared with the control 
      group.
FAU - Mosiewicz, J
AU  - Mosiewicz J
AD  - I Katedry i Kliniki Chorob Wewnetrznych Akademii Medycznej, Lublinie.
FAU - Myslinski, W
AU  - Myslinski W
FAU - Ryczak, E
AU  - Ryczak E
FAU - Dzida, G
AU  - Dzida G
FAU - Bilan, A
AU  - Bilan A
FAU - Palusinski, R
AU  - Palusinski R
FAU - Hanzlik, J
AU  - Hanzlik J
LA  - pol
PT  - Journal Article
TT  - Nadreaktywnosc oskrzeli jako czynnik ryzyka rozwoju przewleklej obturacyjnej 
      choroby pluc w populacji gornikow kopalni wegla kamiennego w Bogdance.
PL  - Poland
TA  - Med Pr
JT  - Medycyna pracy
JID - 0376642
SB  - IM
MH  - Adult
MH  - Asthma/*physiopathology
MH  - Bronchial Hyperreactivity/*physiopathology
MH  - Catchment Area, Health
MH  - *Coal Mining
MH  - Female
MH  - Humans
MH  - Lung Diseases, Obstructive/diagnosis/*epidemiology
MH  - Male
MH  - Occupational Diseases/diagnosis/*epidemiology
MH  - Poland/epidemiology
EDAT- 2000/04/04 09:00
MHDA- 2000/05/08 09:00
CRDT- 2000/04/04 09:00
PHST- 2000/04/04 09:00 [pubmed]
PHST- 2000/05/08 09:00 [medline]
PHST- 2000/04/04 09:00 [entrez]
PST - ppublish
SO  - Med Pr. 1999;50(6):537-47.